Molecular dynamics simulations of the conformational plasticity in the active pocket of salt-inducible kinase 2 (SIK2) multi-state binding with bosutinib

The kinase domain is highly conserved among protein kinases 'in terms of both sequence and structure. Conformational rearrangements of the kinase domain are affected by the phosphorylation of residues and the binding of kinase inhibitors. Interestingly, the conformational rearrangement of the a...

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Detalles Bibliográficos
Autores principales: Shi, Mingsong, Wang, Lun, Liu, Kongjun, Chen, Yong, Hu, Mengshi, Yang, Linyu, He, Jun, Chen, Lijuan, Xu, Dingguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160496/
https://www.ncbi.nlm.nih.gov/pubmed/35685353
http://dx.doi.org/10.1016/j.csbj.2022.05.039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160496/
https://www.ncbi.nlm.nih.gov/pubmed/35685353
http://dx.doi.org/10.1016/j.csbj.2022.05.039

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