Cargando…

Sleep Deprivation During Memory Consolidation, but Not Before Memory Retrieval, Widens Threat Generalization to New Stimuli

Past aversive experiences shape our ability to deal with future dangers, through the encoding of implicit and explicit memory traces and through the ability to generalize defensive reactions to new stimuli resembling learned threats. Numerous evidence demonstrate that sleep is important for the cons...

Descripción completa

Detalles Bibliográficos
Autores principales: Manassero, Eugenio, Giordano, Alessandra, Raimondo, Erika, Cicolin, Alessandro, Sacchetti, Benedetto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160568/
https://www.ncbi.nlm.nih.gov/pubmed/35663560
http://dx.doi.org/10.3389/fnins.2022.902925
_version_ 1784719292270379008
author Manassero, Eugenio
Giordano, Alessandra
Raimondo, Erika
Cicolin, Alessandro
Sacchetti, Benedetto
author_facet Manassero, Eugenio
Giordano, Alessandra
Raimondo, Erika
Cicolin, Alessandro
Sacchetti, Benedetto
author_sort Manassero, Eugenio
collection PubMed
description Past aversive experiences shape our ability to deal with future dangers, through the encoding of implicit and explicit memory traces and through the ability to generalize defensive reactions to new stimuli resembling learned threats. Numerous evidence demonstrate that sleep is important for the consolidation of memories related to threatening events. However, there is a lack of studies examining the effects of sleep deprivation on the retrieval of consolidated threat memories, and previous studies on the role of sleep in threat generalization have produced mixed results. To address these issues, here we adopted a differential threat conditioning and a delayed (second half of the night) sleep deprivation during the first or the seventh night after learning. We found no effects of sleep deprivation on either implicit or explicit threat memories, regardless of its occurrence timing. Conversely, implicit but not explicit responses to novel cues similar to a learned threat displayed a widened generalization pattern, but only if sleep deprivation took place during the first night after conditioning and not if it occurred during the seventh night after conditioning. Therefore, we propose that sleeping after exposure to danger may support optimal implicit discrimination processes to evaluate new signals in the future and that even a brief period of sleeplessness may widen threat generalization to new stimuli, which is a hallmark of several threat-related disorders.
format Online
Article
Text
id pubmed-9160568
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91605682022-06-03 Sleep Deprivation During Memory Consolidation, but Not Before Memory Retrieval, Widens Threat Generalization to New Stimuli Manassero, Eugenio Giordano, Alessandra Raimondo, Erika Cicolin, Alessandro Sacchetti, Benedetto Front Neurosci Neuroscience Past aversive experiences shape our ability to deal with future dangers, through the encoding of implicit and explicit memory traces and through the ability to generalize defensive reactions to new stimuli resembling learned threats. Numerous evidence demonstrate that sleep is important for the consolidation of memories related to threatening events. However, there is a lack of studies examining the effects of sleep deprivation on the retrieval of consolidated threat memories, and previous studies on the role of sleep in threat generalization have produced mixed results. To address these issues, here we adopted a differential threat conditioning and a delayed (second half of the night) sleep deprivation during the first or the seventh night after learning. We found no effects of sleep deprivation on either implicit or explicit threat memories, regardless of its occurrence timing. Conversely, implicit but not explicit responses to novel cues similar to a learned threat displayed a widened generalization pattern, but only if sleep deprivation took place during the first night after conditioning and not if it occurred during the seventh night after conditioning. Therefore, we propose that sleeping after exposure to danger may support optimal implicit discrimination processes to evaluate new signals in the future and that even a brief period of sleeplessness may widen threat generalization to new stimuli, which is a hallmark of several threat-related disorders. Frontiers Media S.A. 2022-05-19 /pmc/articles/PMC9160568/ /pubmed/35663560 http://dx.doi.org/10.3389/fnins.2022.902925 Text en Copyright © 2022 Manassero, Giordano, Raimondo, Cicolin and Sacchetti. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Manassero, Eugenio
Giordano, Alessandra
Raimondo, Erika
Cicolin, Alessandro
Sacchetti, Benedetto
Sleep Deprivation During Memory Consolidation, but Not Before Memory Retrieval, Widens Threat Generalization to New Stimuli
title Sleep Deprivation During Memory Consolidation, but Not Before Memory Retrieval, Widens Threat Generalization to New Stimuli
title_full Sleep Deprivation During Memory Consolidation, but Not Before Memory Retrieval, Widens Threat Generalization to New Stimuli
title_fullStr Sleep Deprivation During Memory Consolidation, but Not Before Memory Retrieval, Widens Threat Generalization to New Stimuli
title_full_unstemmed Sleep Deprivation During Memory Consolidation, but Not Before Memory Retrieval, Widens Threat Generalization to New Stimuli
title_short Sleep Deprivation During Memory Consolidation, but Not Before Memory Retrieval, Widens Threat Generalization to New Stimuli
title_sort sleep deprivation during memory consolidation, but not before memory retrieval, widens threat generalization to new stimuli
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160568/
https://www.ncbi.nlm.nih.gov/pubmed/35663560
http://dx.doi.org/10.3389/fnins.2022.902925
work_keys_str_mv AT manasseroeugenio sleepdeprivationduringmemoryconsolidationbutnotbeforememoryretrievalwidensthreatgeneralizationtonewstimuli
AT giordanoalessandra sleepdeprivationduringmemoryconsolidationbutnotbeforememoryretrievalwidensthreatgeneralizationtonewstimuli
AT raimondoerika sleepdeprivationduringmemoryconsolidationbutnotbeforememoryretrievalwidensthreatgeneralizationtonewstimuli
AT cicolinalessandro sleepdeprivationduringmemoryconsolidationbutnotbeforememoryretrievalwidensthreatgeneralizationtonewstimuli
AT sacchettibenedetto sleepdeprivationduringmemoryconsolidationbutnotbeforememoryretrievalwidensthreatgeneralizationtonewstimuli