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Autophagy Impairment in App Knock-in Alzheimer’s Model Mice

Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-β peptide (Aβ) amyloidosis. Amyloid precursor protein (APP) knock-in mice exhibit robust Aβ pathology, providing possibilities to determine its effect on protein homeostasis including autophagy. Here we comp...

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Detalles Bibliográficos
Autores principales:	Jiang, Richeng, Shimozawa, Makoto, Mayer, Johanna, Tambaro, Simone, Kumar, Rakesh, Abelein, Axel, Winblad, Bengt, Bogdanovic, Nenad, Nilsson, Per
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160569/ https://www.ncbi.nlm.nih.gov/pubmed/35663567 http://dx.doi.org/10.3389/fnagi.2022.878303

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