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Case Report: Refractory Listeria innocua Meningoencephalitis in a Three-Year-Old Boy

Listeria innocua is widely distributed in the environment and food and is considered a non-pathogenic bacterium for both humans and animals. To our knowledge, only a few cases of L. innocua infection in humans and ruminants have been reported. Moreover, there has been no report on human L. innocua m...

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Autores principales: Liao, Yi, Liu, Lingling, Zhou, Hua, Fang, Feng, Liu, Xinglou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160653/
https://www.ncbi.nlm.nih.gov/pubmed/35664865
http://dx.doi.org/10.3389/fped.2022.857900
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author Liao, Yi
Liu, Lingling
Zhou, Hua
Fang, Feng
Liu, Xinglou
author_facet Liao, Yi
Liu, Lingling
Zhou, Hua
Fang, Feng
Liu, Xinglou
author_sort Liao, Yi
collection PubMed
description Listeria innocua is widely distributed in the environment and food and is considered a non-pathogenic bacterium for both humans and animals. To our knowledge, only a few cases of L. innocua infection in humans and ruminants have been reported. Moreover, there has been no report on human L. innocua meningoencephalitis. Here, we report a case of severe refractory meningoencephalitis in a three-year-old boy after infection with L. innocua. The child’s first symptoms were a runny nose, high fever, and rashes, which quickly progressed to unconsciousness and convulsions. The initial analysis of cerebral spinal fluid revealed remarkably elevated protein levels and increased white blood cells count. The blood culture of the patient in the early stage was positive for L. innocua. In addition, his brain imaging tests were observed dynamically, and the result showed a speedy progression from multiple intracranial abnormal signals to hydrocephalus and interstitial cerebral edema. After receiving antibiotics and symptomatic treatment for nearly 3 months, the patient’s condition improved markedly. However, he still had residual complications such as hydrocephalus. Although L. innocua is considered harmless, it can still cause disease in humans, even severe meningoencephalitis, with rapid progression and poor prognosis. Early discovery, diagnosis, and treatment are necessary to elevate the survival rate and life quality of those patients. Antibiotics should be used with sufficient duration and dosage. Cephalosporins are not suitable for the treatment of L. innocua meningoencephalitis and penicillin antibiotics are preferred for children. The presentation of this case will help to expand our knowledge of Listeria infections and provide a potential candidate for pathogens causing severe childhood central nervous system infection.
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spelling pubmed-91606532022-06-03 Case Report: Refractory Listeria innocua Meningoencephalitis in a Three-Year-Old Boy Liao, Yi Liu, Lingling Zhou, Hua Fang, Feng Liu, Xinglou Front Pediatr Pediatrics Listeria innocua is widely distributed in the environment and food and is considered a non-pathogenic bacterium for both humans and animals. To our knowledge, only a few cases of L. innocua infection in humans and ruminants have been reported. Moreover, there has been no report on human L. innocua meningoencephalitis. Here, we report a case of severe refractory meningoencephalitis in a three-year-old boy after infection with L. innocua. The child’s first symptoms were a runny nose, high fever, and rashes, which quickly progressed to unconsciousness and convulsions. The initial analysis of cerebral spinal fluid revealed remarkably elevated protein levels and increased white blood cells count. The blood culture of the patient in the early stage was positive for L. innocua. In addition, his brain imaging tests were observed dynamically, and the result showed a speedy progression from multiple intracranial abnormal signals to hydrocephalus and interstitial cerebral edema. After receiving antibiotics and symptomatic treatment for nearly 3 months, the patient’s condition improved markedly. However, he still had residual complications such as hydrocephalus. Although L. innocua is considered harmless, it can still cause disease in humans, even severe meningoencephalitis, with rapid progression and poor prognosis. Early discovery, diagnosis, and treatment are necessary to elevate the survival rate and life quality of those patients. Antibiotics should be used with sufficient duration and dosage. Cephalosporins are not suitable for the treatment of L. innocua meningoencephalitis and penicillin antibiotics are preferred for children. The presentation of this case will help to expand our knowledge of Listeria infections and provide a potential candidate for pathogens causing severe childhood central nervous system infection. Frontiers Media S.A. 2022-05-19 /pmc/articles/PMC9160653/ /pubmed/35664865 http://dx.doi.org/10.3389/fped.2022.857900 Text en Copyright © 2022 Liao, Liu, Zhou, Fang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Liao, Yi
Liu, Lingling
Zhou, Hua
Fang, Feng
Liu, Xinglou
Case Report: Refractory Listeria innocua Meningoencephalitis in a Three-Year-Old Boy
title Case Report: Refractory Listeria innocua Meningoencephalitis in a Three-Year-Old Boy
title_full Case Report: Refractory Listeria innocua Meningoencephalitis in a Three-Year-Old Boy
title_fullStr Case Report: Refractory Listeria innocua Meningoencephalitis in a Three-Year-Old Boy
title_full_unstemmed Case Report: Refractory Listeria innocua Meningoencephalitis in a Three-Year-Old Boy
title_short Case Report: Refractory Listeria innocua Meningoencephalitis in a Three-Year-Old Boy
title_sort case report: refractory listeria innocua meningoencephalitis in a three-year-old boy
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160653/
https://www.ncbi.nlm.nih.gov/pubmed/35664865
http://dx.doi.org/10.3389/fped.2022.857900
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