Cargando…
Castleman disease of the pancreas mimicking pancreatic malignancy on (68)Ga-DOTATATE and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report
BACKGROUND: Castleman disease is an uncommon nonclonal lymphoproliferative disorder, which frequently mimics both benign and malignant abnormalities in several regions. Depending on the number of lymph nodes or regions involved, Castleman disease (CD) varies in diagnosis, treatment and prognosis. It...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160689/ https://www.ncbi.nlm.nih.gov/pubmed/35734619 http://dx.doi.org/10.4240/wjgs.v14.i5.514 |
_version_ | 1784719321125093376 |
---|---|
author | Liu, Sheng-Lu Luo, Ming Gou, Hao-Xian Yang, Xiao-Li He, Kai |
author_facet | Liu, Sheng-Lu Luo, Ming Gou, Hao-Xian Yang, Xiao-Li He, Kai |
author_sort | Liu, Sheng-Lu |
collection | PubMed |
description | BACKGROUND: Castleman disease is an uncommon nonclonal lymphoproliferative disorder, which frequently mimics both benign and malignant abnormalities in several regions. Depending on the number of lymph nodes or regions involved, Castleman disease (CD) varies in diagnosis, treatment and prognosis. It rarely occurs in the pancreas alone without any distinct clinical feature and tends to be confused with pancreatic paraganglioma (PGL), neuroendocrine tumors (NETs), and primary tumors, thus impeding proper diagnosis and treatment. CASE SUMMARY: A 28-year-old woman presented with a lesion on the neck of the pancreas, detected by ultrasound during a health examination. Physical examination and laboratory findings were normal. The mass showed hypervascularity on enhanced computed tomography (CT), significantly increased (18)F-fluorodeoxyglucose uptake on positron emission tomography (PET)/CT, and slightly increased somatostatin receptor (SSTR) expression on (68)Ga-DOTATATE PET/CT, suggesting no distant metastases and subdiagnoses such as pancreatic PGL, NET, or primary tumor. Intraoperative pathology suggested lymphatic hyperplasia, and only simple tumor resection was performed. The patient was diagnosed with the hyaline vascular variant of CD, which was confirmed by postoperative immunohistochemistry. The patient was discharged successfully, and no recurrence was observed on regular review. CONCLUSION: High glucose uptake and slightly elevated SSTR expression are potentially new diagnostic features of CD of the pancreas. |
format | Online Article Text |
id | pubmed-9160689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-91606892022-06-21 Castleman disease of the pancreas mimicking pancreatic malignancy on (68)Ga-DOTATATE and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report Liu, Sheng-Lu Luo, Ming Gou, Hao-Xian Yang, Xiao-Li He, Kai World J Gastrointest Surg Case Report BACKGROUND: Castleman disease is an uncommon nonclonal lymphoproliferative disorder, which frequently mimics both benign and malignant abnormalities in several regions. Depending on the number of lymph nodes or regions involved, Castleman disease (CD) varies in diagnosis, treatment and prognosis. It rarely occurs in the pancreas alone without any distinct clinical feature and tends to be confused with pancreatic paraganglioma (PGL), neuroendocrine tumors (NETs), and primary tumors, thus impeding proper diagnosis and treatment. CASE SUMMARY: A 28-year-old woman presented with a lesion on the neck of the pancreas, detected by ultrasound during a health examination. Physical examination and laboratory findings were normal. The mass showed hypervascularity on enhanced computed tomography (CT), significantly increased (18)F-fluorodeoxyglucose uptake on positron emission tomography (PET)/CT, and slightly increased somatostatin receptor (SSTR) expression on (68)Ga-DOTATATE PET/CT, suggesting no distant metastases and subdiagnoses such as pancreatic PGL, NET, or primary tumor. Intraoperative pathology suggested lymphatic hyperplasia, and only simple tumor resection was performed. The patient was diagnosed with the hyaline vascular variant of CD, which was confirmed by postoperative immunohistochemistry. The patient was discharged successfully, and no recurrence was observed on regular review. CONCLUSION: High glucose uptake and slightly elevated SSTR expression are potentially new diagnostic features of CD of the pancreas. Baishideng Publishing Group Inc 2022-05-27 2022-05-27 /pmc/articles/PMC9160689/ /pubmed/35734619 http://dx.doi.org/10.4240/wjgs.v14.i5.514 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Case Report Liu, Sheng-Lu Luo, Ming Gou, Hao-Xian Yang, Xiao-Li He, Kai Castleman disease of the pancreas mimicking pancreatic malignancy on (68)Ga-DOTATATE and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report |
title | Castleman disease of the pancreas mimicking pancreatic malignancy on (68)Ga-DOTATATE and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report |
title_full | Castleman disease of the pancreas mimicking pancreatic malignancy on (68)Ga-DOTATATE and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report |
title_fullStr | Castleman disease of the pancreas mimicking pancreatic malignancy on (68)Ga-DOTATATE and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report |
title_full_unstemmed | Castleman disease of the pancreas mimicking pancreatic malignancy on (68)Ga-DOTATATE and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report |
title_short | Castleman disease of the pancreas mimicking pancreatic malignancy on (68)Ga-DOTATATE and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report |
title_sort | castleman disease of the pancreas mimicking pancreatic malignancy on (68)ga-dotatate and (18)f-fluorodeoxyglucose positron emission tomography/computed tomography: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160689/ https://www.ncbi.nlm.nih.gov/pubmed/35734619 http://dx.doi.org/10.4240/wjgs.v14.i5.514 |
work_keys_str_mv | AT liushenglu castlemandiseaseofthepancreasmimickingpancreaticmalignancyon68gadotatateand18ffluorodeoxyglucosepositronemissiontomographycomputedtomographyacasereport AT luoming castlemandiseaseofthepancreasmimickingpancreaticmalignancyon68gadotatateand18ffluorodeoxyglucosepositronemissiontomographycomputedtomographyacasereport AT gouhaoxian castlemandiseaseofthepancreasmimickingpancreaticmalignancyon68gadotatateand18ffluorodeoxyglucosepositronemissiontomographycomputedtomographyacasereport AT yangxiaoli castlemandiseaseofthepancreasmimickingpancreaticmalignancyon68gadotatateand18ffluorodeoxyglucosepositronemissiontomographycomputedtomographyacasereport AT hekai castlemandiseaseofthepancreasmimickingpancreaticmalignancyon68gadotatateand18ffluorodeoxyglucosepositronemissiontomographycomputedtomographyacasereport |