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Modulation of Lymphocyte Functions in the Microenvironment by Tumor Oncogenic Pathways

Despite the broad application of different immunotherapeutic strategies for the treatment of solid as well as hematopoietic cancers, the efficacy of these therapies is still limited, with only a minority of patients having a long-term benefit resulting in an improved survival rate. In order to incre...

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Autores principales: Seliger, Barbara, Massa, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160824/
https://www.ncbi.nlm.nih.gov/pubmed/35663987
http://dx.doi.org/10.3389/fimmu.2022.883639
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author Seliger, Barbara
Massa, Chiara
author_facet Seliger, Barbara
Massa, Chiara
author_sort Seliger, Barbara
collection PubMed
description Despite the broad application of different immunotherapeutic strategies for the treatment of solid as well as hematopoietic cancers, the efficacy of these therapies is still limited, with only a minority of patients having a long-term benefit resulting in an improved survival rate. In order to increase the response rates of patients to the currently available immunotherapies, a better understanding of the molecular mechanisms underlying the intrinsic and/or extrinsic resistance to treatment is required. There exist increasing evidences that activation of different oncogenic pathways as well as inactivation of tumor suppressor genes (TSG) in tumor cells inhibit the immune cell recognition and influegnce the composition of the tumor microenvironment (TME), thus leading to an impaired anti-tumoral immune response. A deeper understanding of the link between the tumor milieu and genomic alterations of TSGs and oncogenes is indispensable for the optimization of immunotherapies and to predict the patients’ response to these treatments. This review summarizes the role of different cancer-related, oncogene- and TSG-controlled pathways in the context of anti-tumoral immunity and response to different immunotherapies.
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spelling pubmed-91608242022-06-03 Modulation of Lymphocyte Functions in the Microenvironment by Tumor Oncogenic Pathways Seliger, Barbara Massa, Chiara Front Immunol Immunology Despite the broad application of different immunotherapeutic strategies for the treatment of solid as well as hematopoietic cancers, the efficacy of these therapies is still limited, with only a minority of patients having a long-term benefit resulting in an improved survival rate. In order to increase the response rates of patients to the currently available immunotherapies, a better understanding of the molecular mechanisms underlying the intrinsic and/or extrinsic resistance to treatment is required. There exist increasing evidences that activation of different oncogenic pathways as well as inactivation of tumor suppressor genes (TSG) in tumor cells inhibit the immune cell recognition and influegnce the composition of the tumor microenvironment (TME), thus leading to an impaired anti-tumoral immune response. A deeper understanding of the link between the tumor milieu and genomic alterations of TSGs and oncogenes is indispensable for the optimization of immunotherapies and to predict the patients’ response to these treatments. This review summarizes the role of different cancer-related, oncogene- and TSG-controlled pathways in the context of anti-tumoral immunity and response to different immunotherapies. Frontiers Media S.A. 2022-05-19 /pmc/articles/PMC9160824/ /pubmed/35663987 http://dx.doi.org/10.3389/fimmu.2022.883639 Text en Copyright © 2022 Seliger and Massa https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Seliger, Barbara
Massa, Chiara
Modulation of Lymphocyte Functions in the Microenvironment by Tumor Oncogenic Pathways
title Modulation of Lymphocyte Functions in the Microenvironment by Tumor Oncogenic Pathways
title_full Modulation of Lymphocyte Functions in the Microenvironment by Tumor Oncogenic Pathways
title_fullStr Modulation of Lymphocyte Functions in the Microenvironment by Tumor Oncogenic Pathways
title_full_unstemmed Modulation of Lymphocyte Functions in the Microenvironment by Tumor Oncogenic Pathways
title_short Modulation of Lymphocyte Functions in the Microenvironment by Tumor Oncogenic Pathways
title_sort modulation of lymphocyte functions in the microenvironment by tumor oncogenic pathways
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160824/
https://www.ncbi.nlm.nih.gov/pubmed/35663987
http://dx.doi.org/10.3389/fimmu.2022.883639
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