Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits Na(V)1.8 via Interactions With the DI Voltage Sensor and DII Pore Module

Voltage-gated sodium channel Na(V)1.8 regulates transmission of pain signals to the brain. While Na(V)1.8 has the potential to serve as a drug target, the molecular mechanisms that shape Na(V)1.8 gating are not completely understood, particularly mechanisms that couple activation to inactivation. In...

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Detalles Bibliográficos
Autores principales: George, Kiran, Lopez-Mateos, Diego, Abd El-Aziz, Tarek Mohamed, Xiao, Yucheng, Kline, Jake, Bao, Hong, Raza, Syed, Stockand, James D., Cummins, Theodore R., Fornelli, Luca, Rowe, Matthew P., Yarov-Yarovoy, Vladimir, Rowe, Ashlee H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160825/
https://www.ncbi.nlm.nih.gov/pubmed/35662692
http://dx.doi.org/10.3389/fphar.2022.846992

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