Cargando…
Ultra-high frequency ultrasound delineated changes in carotid and muscular artery intima-media and adventitia thickness in obese early middle-aged women
Obesity is linked to increased arterial size, carotid intima-media thickness and arterial stiffness. The effects of obesity and body composition on muscular artery intima-media and adventitia thickness has previously not been established. The aim of this study was to explore associations between car...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160911/ https://www.ncbi.nlm.nih.gov/pubmed/35637577 http://dx.doi.org/10.1177/14791641221094321 |
_version_ | 1784719372794724352 |
---|---|
author | Sundholm, Johnny KM Litwin, Linda Rönö, Kristiina Koivusalo, Saila B Eriksson, Johan G Sarkola, Taisto |
author_facet | Sundholm, Johnny KM Litwin, Linda Rönö, Kristiina Koivusalo, Saila B Eriksson, Johan G Sarkola, Taisto |
author_sort | Sundholm, Johnny KM |
collection | PubMed |
description | Obesity is linked to increased arterial size, carotid intima-media thickness and arterial stiffness. The effects of obesity and body composition on muscular artery intima-media and adventitia thickness has previously not been established. The aim of this study was to explore associations between carotid and muscular artery wall layer thickness with body composition and cardiovascular risk factors in early middle-aged women. This is a cross-sectional study including 199 women aged 40±4 years. Arterial lumen (LD), intima-media (IMT) and adventitia thickness (AT) were measured from carotid, brachial and radial arteries using ultra-high frequency ultrasound (22-71 MHz). Women with obesity had increased IMT in carotid (0.47 vs 0.45 mm), brachial (0.19 vs 0.17 mm) and radial arteries (0.16 vs 0.15 mm) and increased brachial AT (0.14 vs 0.13 mm). In multiple regression models all arterial LD (β-range 0.02-0.03 mm/kg/m(2)), IMT (β-range 0.91-3.37 µm/kg/m(2)), AT (β-range 0.73-1.38 µm/kg/m(2)) were significantly associated with BMI. The IMT of all arteries were significantly associated with systolic blood pressure (β-range 0.36-0.85 µm/mmHg), attenuating the association between IMT and BMI (β-range 0.18-2.24 µm/kg/m(2)). Obese early middle-aged women have increased arterial intima media thickness and brachial artery adventitia thickness compared to non-obese counterparts. The association between BMI and intima-media thickness is partly mediated through blood pressure levels. |
format | Online Article Text |
id | pubmed-9160911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-91609112022-06-03 Ultra-high frequency ultrasound delineated changes in carotid and muscular artery intima-media and adventitia thickness in obese early middle-aged women Sundholm, Johnny KM Litwin, Linda Rönö, Kristiina Koivusalo, Saila B Eriksson, Johan G Sarkola, Taisto Diab Vasc Dis Res Original Article Obesity is linked to increased arterial size, carotid intima-media thickness and arterial stiffness. The effects of obesity and body composition on muscular artery intima-media and adventitia thickness has previously not been established. The aim of this study was to explore associations between carotid and muscular artery wall layer thickness with body composition and cardiovascular risk factors in early middle-aged women. This is a cross-sectional study including 199 women aged 40±4 years. Arterial lumen (LD), intima-media (IMT) and adventitia thickness (AT) were measured from carotid, brachial and radial arteries using ultra-high frequency ultrasound (22-71 MHz). Women with obesity had increased IMT in carotid (0.47 vs 0.45 mm), brachial (0.19 vs 0.17 mm) and radial arteries (0.16 vs 0.15 mm) and increased brachial AT (0.14 vs 0.13 mm). In multiple regression models all arterial LD (β-range 0.02-0.03 mm/kg/m(2)), IMT (β-range 0.91-3.37 µm/kg/m(2)), AT (β-range 0.73-1.38 µm/kg/m(2)) were significantly associated with BMI. The IMT of all arteries were significantly associated with systolic blood pressure (β-range 0.36-0.85 µm/mmHg), attenuating the association between IMT and BMI (β-range 0.18-2.24 µm/kg/m(2)). Obese early middle-aged women have increased arterial intima media thickness and brachial artery adventitia thickness compared to non-obese counterparts. The association between BMI and intima-media thickness is partly mediated through blood pressure levels. SAGE Publications 2022-05-30 /pmc/articles/PMC9160911/ /pubmed/35637577 http://dx.doi.org/10.1177/14791641221094321 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Sundholm, Johnny KM Litwin, Linda Rönö, Kristiina Koivusalo, Saila B Eriksson, Johan G Sarkola, Taisto Ultra-high frequency ultrasound delineated changes in carotid and muscular artery intima-media and adventitia thickness in obese early middle-aged women |
title | Ultra-high frequency ultrasound delineated changes in carotid and muscular artery intima-media and adventitia thickness in obese early middle-aged women |
title_full | Ultra-high frequency ultrasound delineated changes in carotid and muscular artery intima-media and adventitia thickness in obese early middle-aged women |
title_fullStr | Ultra-high frequency ultrasound delineated changes in carotid and muscular artery intima-media and adventitia thickness in obese early middle-aged women |
title_full_unstemmed | Ultra-high frequency ultrasound delineated changes in carotid and muscular artery intima-media and adventitia thickness in obese early middle-aged women |
title_short | Ultra-high frequency ultrasound delineated changes in carotid and muscular artery intima-media and adventitia thickness in obese early middle-aged women |
title_sort | ultra-high frequency ultrasound delineated changes in carotid and muscular artery intima-media and adventitia thickness in obese early middle-aged women |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160911/ https://www.ncbi.nlm.nih.gov/pubmed/35637577 http://dx.doi.org/10.1177/14791641221094321 |
work_keys_str_mv | AT sundholmjohnnykm ultrahighfrequencyultrasounddelineatedchangesincarotidandmusculararteryintimamediaandadventitiathicknessinobeseearlymiddleagedwomen AT litwinlinda ultrahighfrequencyultrasounddelineatedchangesincarotidandmusculararteryintimamediaandadventitiathicknessinobeseearlymiddleagedwomen AT ronokristiina ultrahighfrequencyultrasounddelineatedchangesincarotidandmusculararteryintimamediaandadventitiathicknessinobeseearlymiddleagedwomen AT koivusalosailab ultrahighfrequencyultrasounddelineatedchangesincarotidandmusculararteryintimamediaandadventitiathicknessinobeseearlymiddleagedwomen AT erikssonjohang ultrahighfrequencyultrasounddelineatedchangesincarotidandmusculararteryintimamediaandadventitiathicknessinobeseearlymiddleagedwomen AT sarkolataisto ultrahighfrequencyultrasounddelineatedchangesincarotidandmusculararteryintimamediaandadventitiathicknessinobeseearlymiddleagedwomen |