Splenic rupture following lenograstim in post-autologous stem cell transplantation treated with emergency open splenectomy: a case report and literature review

Granulocyte-colony stimulating factors (G-CSFs) are the cornerstone of peripheral blood stem cell mobilization and apheresis. However, splenic rupture following G-CSF treatment represents a serious and potentially fatal adverse event. Here, we report the case of a patient in their late 50s with seve...

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Autores principales: Markovic, Uros, Colarossi, Cristina, Iuppa, Antonio, Scire, Paola, Gorgone, Ausilia, Galbo, Federica, Amato, Gabriella, Moschetti, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160916/
https://www.ncbi.nlm.nih.gov/pubmed/35638556
http://dx.doi.org/10.1177/03000605221095504
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author Markovic, Uros
Colarossi, Cristina
Iuppa, Antonio
Scire, Paola
Gorgone, Ausilia
Galbo, Federica
Amato, Gabriella
Moschetti, Gaetano
author_facet Markovic, Uros
Colarossi, Cristina
Iuppa, Antonio
Scire, Paola
Gorgone, Ausilia
Galbo, Federica
Amato, Gabriella
Moschetti, Gaetano
author_sort Markovic, Uros
collection PubMed
description Granulocyte-colony stimulating factors (G-CSFs) are the cornerstone of peripheral blood stem cell mobilization and apheresis. However, splenic rupture following G-CSF treatment represents a serious and potentially fatal adverse event. Here, we report the case of a patient in their late 50s with severe pancytopenia post-autologous stem cell transplantation reinfusion suffering from splenic rupture after treatment with lenograstim. We also reviewed the literature describing cases of splenic rupture during G-CSF administration.
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spelling pubmed-91609162022-06-03 Splenic rupture following lenograstim in post-autologous stem cell transplantation treated with emergency open splenectomy: a case report and literature review Markovic, Uros Colarossi, Cristina Iuppa, Antonio Scire, Paola Gorgone, Ausilia Galbo, Federica Amato, Gabriella Moschetti, Gaetano J Int Med Res Case Reports Granulocyte-colony stimulating factors (G-CSFs) are the cornerstone of peripheral blood stem cell mobilization and apheresis. However, splenic rupture following G-CSF treatment represents a serious and potentially fatal adverse event. Here, we report the case of a patient in their late 50s with severe pancytopenia post-autologous stem cell transplantation reinfusion suffering from splenic rupture after treatment with lenograstim. We also reviewed the literature describing cases of splenic rupture during G-CSF administration. SAGE Publications 2022-05-31 /pmc/articles/PMC9160916/ /pubmed/35638556 http://dx.doi.org/10.1177/03000605221095504 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Markovic, Uros
Colarossi, Cristina
Iuppa, Antonio
Scire, Paola
Gorgone, Ausilia
Galbo, Federica
Amato, Gabriella
Moschetti, Gaetano
Splenic rupture following lenograstim in post-autologous stem cell transplantation treated with emergency open splenectomy: a case report and literature review
title Splenic rupture following lenograstim in post-autologous stem cell transplantation treated with emergency open splenectomy: a case report and literature review
title_full Splenic rupture following lenograstim in post-autologous stem cell transplantation treated with emergency open splenectomy: a case report and literature review
title_fullStr Splenic rupture following lenograstim in post-autologous stem cell transplantation treated with emergency open splenectomy: a case report and literature review
title_full_unstemmed Splenic rupture following lenograstim in post-autologous stem cell transplantation treated with emergency open splenectomy: a case report and literature review
title_short Splenic rupture following lenograstim in post-autologous stem cell transplantation treated with emergency open splenectomy: a case report and literature review
title_sort splenic rupture following lenograstim in post-autologous stem cell transplantation treated with emergency open splenectomy: a case report and literature review
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160916/
https://www.ncbi.nlm.nih.gov/pubmed/35638556
http://dx.doi.org/10.1177/03000605221095504
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