Cargando…

Association of Gut Microbiota and Biochemical Features in a Chinese Population With Renal Uric Acid Stone

Previous studies suggest that patients with nephrolithiasis exhibit dysbiosis in their gut microbiota, but those studies were conducted in calcium oxalate stone patients. We aimed to explore the association of gut microbiota and biochemical features of renal uric acid stone (UAS) patients in a Chine...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Cheng, Fan, Bo, Zhu, Jin, Zhu, Na, Cao, Jing-Yuan, Yang, Dong-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160931/
https://www.ncbi.nlm.nih.gov/pubmed/35662733
http://dx.doi.org/10.3389/fphar.2022.888883
_version_ 1784719377730371584
author Cao, Cheng
Fan, Bo
Zhu, Jin
Zhu, Na
Cao, Jing-Yuan
Yang, Dong-Rong
author_facet Cao, Cheng
Fan, Bo
Zhu, Jin
Zhu, Na
Cao, Jing-Yuan
Yang, Dong-Rong
author_sort Cao, Cheng
collection PubMed
description Previous studies suggest that patients with nephrolithiasis exhibit dysbiosis in their gut microbiota, but those studies were conducted in calcium oxalate stone patients. We aimed to explore the association of gut microbiota and biochemical features of renal uric acid stone (UAS) patients in a Chinese population and identify the related bacteria that may affect the pathopoiesis of UAS. A case-control study of 117 patients with UAS, 123 patients with gout, and 135 healthy controls were included from January 2014 to October 2020. For each subject, data on demographics, biochemical parameters of blood and urine were analyzed. Fifteen patients with gout, 16 patients with UAS, 17 UAS patients with gout, and 17 healthy subjects were enrolled and provided fecal samples. The characteristics of gut microbiota were explored by using 16S ribosomal RNA (rRNA) gene sequencing and analyzed by using a combination of software mother and R. Hyperuricemia was the main risk factor for the development of gout and UAS. Obesity, dyslipidemia, and aciduria were unique risk factors for UAS patients. The richness, diversity, and relative abundance of dominant bacteria at the phylum and genus levels of gut microbiota in UAS patients were significantly distinct from other subjects. Abundance of Bacteroides and Fusobacterium was significantly positively correlated with the serum uric acid (UA) level of UAS patients. Fusobacteria was involved in the metabolism and degradation of certain short-chain fatty acids, amino acids, and sugars in pathopoiesis of UAS, and inhibited their synthesis pathways. Fusobacteria may be related to the pathogenesis of UAS, and this finding contributes to the personalized treatment of UAS from the perspective of maintaining micro-ecological equilibrium in gut.
format Online
Article
Text
id pubmed-9160931
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91609312022-06-03 Association of Gut Microbiota and Biochemical Features in a Chinese Population With Renal Uric Acid Stone Cao, Cheng Fan, Bo Zhu, Jin Zhu, Na Cao, Jing-Yuan Yang, Dong-Rong Front Pharmacol Pharmacology Previous studies suggest that patients with nephrolithiasis exhibit dysbiosis in their gut microbiota, but those studies were conducted in calcium oxalate stone patients. We aimed to explore the association of gut microbiota and biochemical features of renal uric acid stone (UAS) patients in a Chinese population and identify the related bacteria that may affect the pathopoiesis of UAS. A case-control study of 117 patients with UAS, 123 patients with gout, and 135 healthy controls were included from January 2014 to October 2020. For each subject, data on demographics, biochemical parameters of blood and urine were analyzed. Fifteen patients with gout, 16 patients with UAS, 17 UAS patients with gout, and 17 healthy subjects were enrolled and provided fecal samples. The characteristics of gut microbiota were explored by using 16S ribosomal RNA (rRNA) gene sequencing and analyzed by using a combination of software mother and R. Hyperuricemia was the main risk factor for the development of gout and UAS. Obesity, dyslipidemia, and aciduria were unique risk factors for UAS patients. The richness, diversity, and relative abundance of dominant bacteria at the phylum and genus levels of gut microbiota in UAS patients were significantly distinct from other subjects. Abundance of Bacteroides and Fusobacterium was significantly positively correlated with the serum uric acid (UA) level of UAS patients. Fusobacteria was involved in the metabolism and degradation of certain short-chain fatty acids, amino acids, and sugars in pathopoiesis of UAS, and inhibited their synthesis pathways. Fusobacteria may be related to the pathogenesis of UAS, and this finding contributes to the personalized treatment of UAS from the perspective of maintaining micro-ecological equilibrium in gut. Frontiers Media S.A. 2022-05-19 /pmc/articles/PMC9160931/ /pubmed/35662733 http://dx.doi.org/10.3389/fphar.2022.888883 Text en Copyright © 2022 Cao, Fan, Zhu, Zhu, Cao and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Cao, Cheng
Fan, Bo
Zhu, Jin
Zhu, Na
Cao, Jing-Yuan
Yang, Dong-Rong
Association of Gut Microbiota and Biochemical Features in a Chinese Population With Renal Uric Acid Stone
title Association of Gut Microbiota and Biochemical Features in a Chinese Population With Renal Uric Acid Stone
title_full Association of Gut Microbiota and Biochemical Features in a Chinese Population With Renal Uric Acid Stone
title_fullStr Association of Gut Microbiota and Biochemical Features in a Chinese Population With Renal Uric Acid Stone
title_full_unstemmed Association of Gut Microbiota and Biochemical Features in a Chinese Population With Renal Uric Acid Stone
title_short Association of Gut Microbiota and Biochemical Features in a Chinese Population With Renal Uric Acid Stone
title_sort association of gut microbiota and biochemical features in a chinese population with renal uric acid stone
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160931/
https://www.ncbi.nlm.nih.gov/pubmed/35662733
http://dx.doi.org/10.3389/fphar.2022.888883
work_keys_str_mv AT caocheng associationofgutmicrobiotaandbiochemicalfeaturesinachinesepopulationwithrenaluricacidstone
AT fanbo associationofgutmicrobiotaandbiochemicalfeaturesinachinesepopulationwithrenaluricacidstone
AT zhujin associationofgutmicrobiotaandbiochemicalfeaturesinachinesepopulationwithrenaluricacidstone
AT zhuna associationofgutmicrobiotaandbiochemicalfeaturesinachinesepopulationwithrenaluricacidstone
AT caojingyuan associationofgutmicrobiotaandbiochemicalfeaturesinachinesepopulationwithrenaluricacidstone
AT yangdongrong associationofgutmicrobiotaandbiochemicalfeaturesinachinesepopulationwithrenaluricacidstone