Assessing the Impact of Continuous Vaccination and Voluntary Isolation on the Dynamics of COVID-19: A Mathematical Optimal Control of SEIR Epidemic Model

In order to study the impact of continuous vaccination and voluntary isolation for the COVID-19, a susceptible-exposed-infected-recovered-quarantine-vaccines (SEIR-QV) model is proposed. A basic regeneration number R(0) is defined to determine the extinction or persistence of the disease. We numerically analyze the impact of key parameters based on actual parameters of COVID-19, such as the vaccination rate, population importation rate, and natural (or causal) mortality transmission rate on the dynamics of disease transmission. Then we obtain sensitivity indices of some parameters on R(0) by sensitivity analysis. Finally, the stability of the system and the effectiveness of the optimal control strategy are verified by numerical simulation.