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Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime

EFSA received a mandate from the European Commission to assess the risks related to a possible reduction of the waiting period after rabies antibody titration test to 30 days compared with 90 days of the current EU legislation, for dogs moving from certain non‐EU countries to the EU. This Scientific...

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Autores principales: Alvarez, Julio, Nielsen, Søren Saxmose, Robardet, Emmanuelle, Stegeman, Arjan, Van Gucht, Steven, Vuta, Vlad, Antoniou, Sotiria‐Eleni, Aznar, Inma, Papanikolaou, Alexandra, Roberts, Helen Clare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161159/
https://www.ncbi.nlm.nih.gov/pubmed/35662806
http://dx.doi.org/10.2903/j.efsa.2022.7350
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author Alvarez, Julio
Nielsen, Søren Saxmose
Robardet, Emmanuelle
Stegeman, Arjan
Van Gucht, Steven
Vuta, Vlad
Antoniou, Sotiria‐Eleni
Aznar, Inma
Papanikolaou, Alexandra
Roberts, Helen Clare
author_facet Alvarez, Julio
Nielsen, Søren Saxmose
Robardet, Emmanuelle
Stegeman, Arjan
Van Gucht, Steven
Vuta, Vlad
Antoniou, Sotiria‐Eleni
Aznar, Inma
Papanikolaou, Alexandra
Roberts, Helen Clare
collection PubMed
description EFSA received a mandate from the European Commission to assess the risks related to a possible reduction of the waiting period after rabies antibody titration test to 30 days compared with 90 days of the current EU legislation, for dogs moving from certain non‐EU countries to the EU. This Scientific Report assessed the probability of introduction of rabies into the EU through commercial and non‐commercial movements of vaccinated dogs with a positive titration test (≥ 0.5 IU/mL) if the waiting period decreases from 90 to 30 days. Assuming that all the legal requirements are complied with, the risk of transmission of rabies through the movement of a vaccinated dog is related to the risk of introducing an animal incubating rabies that was infected before the day of vaccination or shortly after vaccination but before the development of immunity (21 days post‐vaccination). Using published data on the incubation period for experimental and field cases in dogs and considering the rabies incidence data in certain countries, the aggregated probability for the annual introduction of rabies through dogs was assessed. Considering the uncertainty related to the duration of the incubation period, the number of imported dogs, and the disease incidence in some countries it was concluded with a 95% certainty that the maximum number of rabies‐infected imported dogs complying with the regulations in a 20‐year period could increase from 5 to 20 when decreasing the waiting period from 90 to 30 days. Nevertheless, the potential impact of even a small increase in probability means the risk is increased for a region like the EU where rabies has long been a focus for eradication, to protect human and animal health.
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spelling pubmed-91611592022-06-04 Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime Alvarez, Julio Nielsen, Søren Saxmose Robardet, Emmanuelle Stegeman, Arjan Van Gucht, Steven Vuta, Vlad Antoniou, Sotiria‐Eleni Aznar, Inma Papanikolaou, Alexandra Roberts, Helen Clare EFSA J Scientific Opinion EFSA received a mandate from the European Commission to assess the risks related to a possible reduction of the waiting period after rabies antibody titration test to 30 days compared with 90 days of the current EU legislation, for dogs moving from certain non‐EU countries to the EU. This Scientific Report assessed the probability of introduction of rabies into the EU through commercial and non‐commercial movements of vaccinated dogs with a positive titration test (≥ 0.5 IU/mL) if the waiting period decreases from 90 to 30 days. Assuming that all the legal requirements are complied with, the risk of transmission of rabies through the movement of a vaccinated dog is related to the risk of introducing an animal incubating rabies that was infected before the day of vaccination or shortly after vaccination but before the development of immunity (21 days post‐vaccination). Using published data on the incubation period for experimental and field cases in dogs and considering the rabies incidence data in certain countries, the aggregated probability for the annual introduction of rabies through dogs was assessed. Considering the uncertainty related to the duration of the incubation period, the number of imported dogs, and the disease incidence in some countries it was concluded with a 95% certainty that the maximum number of rabies‐infected imported dogs complying with the regulations in a 20‐year period could increase from 5 to 20 when decreasing the waiting period from 90 to 30 days. Nevertheless, the potential impact of even a small increase in probability means the risk is increased for a region like the EU where rabies has long been a focus for eradication, to protect human and animal health. John Wiley and Sons Inc. 2022-06-02 /pmc/articles/PMC9161159/ /pubmed/35662806 http://dx.doi.org/10.2903/j.efsa.2022.7350 Text en © 2022 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Alvarez, Julio
Nielsen, Søren Saxmose
Robardet, Emmanuelle
Stegeman, Arjan
Van Gucht, Steven
Vuta, Vlad
Antoniou, Sotiria‐Eleni
Aznar, Inma
Papanikolaou, Alexandra
Roberts, Helen Clare
Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime
title Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime
title_full Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime
title_fullStr Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime
title_full_unstemmed Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime
title_short Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime
title_sort risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current eu legislative regime
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161159/
https://www.ncbi.nlm.nih.gov/pubmed/35662806
http://dx.doi.org/10.2903/j.efsa.2022.7350
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