Cargando…

Comparison of Immune Responses Elicited by SARS-CoV-2 mRNA and Recombinant Protein Vaccine Candidates

After the outbreak of COVID-19, billions of vaccines with different types have been administrated, including recombinant protein vaccines and mRNA vaccines. Although both types of SARS-CoV-2 vaccine can protect people from viral infection, their differences in humoral and cellular immune responses a...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Yixin, Zhang, Huicong, Meng, Liuxian, Li, Fusheng, Yu, Changyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161160/
https://www.ncbi.nlm.nih.gov/pubmed/35663946
http://dx.doi.org/10.3389/fimmu.2022.906457
_version_ 1784719424311263232
author Wu, Yixin
Zhang, Huicong
Meng, Liuxian
Li, Fusheng
Yu, Changyuan
author_facet Wu, Yixin
Zhang, Huicong
Meng, Liuxian
Li, Fusheng
Yu, Changyuan
author_sort Wu, Yixin
collection PubMed
description After the outbreak of COVID-19, billions of vaccines with different types have been administrated, including recombinant protein vaccines and mRNA vaccines. Although both types of SARS-CoV-2 vaccine can protect people from viral infection, their differences in humoral and cellular immune responses are still not clearly understood. In this study, we made a head-to-head comparison between an mRNA vaccine candidate and a recombinant protein vaccine we developed previously. Results demonstrated that both vaccine candidates could elicit high specific binding and neutralizing antibody titers in BALB/c mice, but with bias towards different IgG subtypes. Besides, the mRNA vaccine candidate induces higher cellular immune responses than the recombinant protein vaccine. To date, this is the first reported study to directly compare the immune responses of both arms between SARS-CoV-2 mRNA and recombinant vaccines.
format Online
Article
Text
id pubmed-9161160
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91611602022-06-03 Comparison of Immune Responses Elicited by SARS-CoV-2 mRNA and Recombinant Protein Vaccine Candidates Wu, Yixin Zhang, Huicong Meng, Liuxian Li, Fusheng Yu, Changyuan Front Immunol Immunology After the outbreak of COVID-19, billions of vaccines with different types have been administrated, including recombinant protein vaccines and mRNA vaccines. Although both types of SARS-CoV-2 vaccine can protect people from viral infection, their differences in humoral and cellular immune responses are still not clearly understood. In this study, we made a head-to-head comparison between an mRNA vaccine candidate and a recombinant protein vaccine we developed previously. Results demonstrated that both vaccine candidates could elicit high specific binding and neutralizing antibody titers in BALB/c mice, but with bias towards different IgG subtypes. Besides, the mRNA vaccine candidate induces higher cellular immune responses than the recombinant protein vaccine. To date, this is the first reported study to directly compare the immune responses of both arms between SARS-CoV-2 mRNA and recombinant vaccines. Frontiers Media S.A. 2022-05-19 /pmc/articles/PMC9161160/ /pubmed/35663946 http://dx.doi.org/10.3389/fimmu.2022.906457 Text en Copyright © 2022 Wu, Zhang, Meng, Li and Yu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wu, Yixin
Zhang, Huicong
Meng, Liuxian
Li, Fusheng
Yu, Changyuan
Comparison of Immune Responses Elicited by SARS-CoV-2 mRNA and Recombinant Protein Vaccine Candidates
title Comparison of Immune Responses Elicited by SARS-CoV-2 mRNA and Recombinant Protein Vaccine Candidates
title_full Comparison of Immune Responses Elicited by SARS-CoV-2 mRNA and Recombinant Protein Vaccine Candidates
title_fullStr Comparison of Immune Responses Elicited by SARS-CoV-2 mRNA and Recombinant Protein Vaccine Candidates
title_full_unstemmed Comparison of Immune Responses Elicited by SARS-CoV-2 mRNA and Recombinant Protein Vaccine Candidates
title_short Comparison of Immune Responses Elicited by SARS-CoV-2 mRNA and Recombinant Protein Vaccine Candidates
title_sort comparison of immune responses elicited by sars-cov-2 mrna and recombinant protein vaccine candidates
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161160/
https://www.ncbi.nlm.nih.gov/pubmed/35663946
http://dx.doi.org/10.3389/fimmu.2022.906457
work_keys_str_mv AT wuyixin comparisonofimmuneresponseselicitedbysarscov2mrnaandrecombinantproteinvaccinecandidates
AT zhanghuicong comparisonofimmuneresponseselicitedbysarscov2mrnaandrecombinantproteinvaccinecandidates
AT mengliuxian comparisonofimmuneresponseselicitedbysarscov2mrnaandrecombinantproteinvaccinecandidates
AT lifusheng comparisonofimmuneresponseselicitedbysarscov2mrnaandrecombinantproteinvaccinecandidates
AT yuchangyuan comparisonofimmuneresponseselicitedbysarscov2mrnaandrecombinantproteinvaccinecandidates