Cargando…

Towards the discovery of potential RdRp inhibitors for the treatment of COVID-19: structure guided virtual screening, computational ADME and molecular dynamics study

Coronavirus disease 2019 (COVID-19) has become a major challenge affecting almost every corner of the world, with more than five million deaths worldwide. Despite several efforts, no drug or vaccine has shown the potential to check the ever-mutating SARS-COV-2. The emergence of novel variants is a m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alam, Aftab, Agrawal, Gopal Prasad, Khan, Shamshir, Khalilullah, Habibullah, Saifullah, Muhammed Khalid, Arshad, Mohammed Faiz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161180/ https://www.ncbi.nlm.nih.gov/pubmed/35669792 http://dx.doi.org/10.1007/s11224-022-01976-2

Ejemplares similares

RdRp or RT, That is the Question
por: Peyambari, Mahtab, et al.
Publicado: (2021)

Snapshots of a Non-Canonical RdRP in Action
por: Ferrero, Diego S., et al.
Publicado: (2021)

Aging correlates with lower threshold cycle values for RdRP/RdRP+S genes during molecular detection of SARS-CoV-2
por: Mikuła-Pietrasik, Justyna, et al.
Publicado: (2021)

In silico investigation to identify potential small molecule inhibitors of the RNA-dependent RNA polymerase (RdRp) nidovirus RdRp-associated nucleotidyltransferase domain
por: Pitsillou, Eleni, et al.
Publicado: (2021)

Inhibition of HEV Replication by FDA-Approved RdRp Inhibitors
por: Hooda, Preeti, et al.
Publicado: (2023)

Discovery of divided RdRp sequences and a hitherto unknown genomic complexity in fungal viruses
por: Chiba, Yuto, et al.
Publicado: (2020)

The potential of Paritaprevir and Emetine as inhibitors of SARS-CoV-2 RdRp
por: Gurung, Arun Bahadur, et al.
Publicado: (2021)

Evaluation of potential anti-RNA-dependent RNA polymerase (RdRP) drugs against the newly emerged model of COVID-19 RdRP using computational methods
por: Poustforoosh, Alireza, et al.
Publicado: (2021)

SARS-CoV-2 RdRp Inhibitors Selected from a Cell-Based SARS-CoV-2 RdRp Activity Assay System
por: Min, Jung Sun, et al.
Publicado: (2021)

Erratum: Discovery of divided RdRp sequences and a hitherto unknown genomic complexity in fungal viruses
por: Chiba, Yuto, et al.
Publicado: (2021)

RdRp inhibitors and COVID-19: Is molnupiravir a good option?
por: Hashemian, Seyed Mohammad Reza, et al.
Publicado: (2022)

Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity
por: Painter, Meghan M., et al.
Publicado: (2015)

RdRp mutations are associated with SARS-CoV-2 genome evolution
por: Eskier, Doğa, et al.
Publicado: (2020)

RdRp-based sensitive taxonomic classification of RNA viruses for metagenomic data
por: Tang, Xubo, et al.
Publicado: (2022)

Analysis of the codon usage pattern of the RdRP gene of mycovirus infecting Aspergillus spp.
por: Je, Mikyung, et al.
Publicado: (2019)

Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge
por: Picarazzi, Francesca, et al.
Publicado: (2020)

RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review
por: Leite, Daniela Regina Buch, et al.
Publicado: (2022)

In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation
por: Bao, Keyan, et al.
Publicado: (2022)

Identification of RNA Virus–Derived RdRp Sequences in Publicly Available Transcriptomic Data Sets
por: Olendraite, Ingrida, et al.
Publicado: (2023)

Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases
por: Riccio, Federica, et al.
Publicado: (2019)

Antibiotic fidaxomicin is an RdRp inhibitor as a potential new therapeutic agent against Zika virus
por: Yuan, Jie, et al.
Publicado: (2020)

Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2
por: Arba, Muhammad, et al.
Publicado: (2021)

RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic
por: Tian, Lei, et al.
Publicado: (2021)

Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)
por: Wu, Yifei, et al.
Publicado: (2021)

Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides
por: Wang, Bing, et al.
Publicado: (2021)

Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2
por: Shawan, Mohammad Mahfuz Ali Khan, et al.
Publicado: (2021)

Azelnidipine Exhibits In Vitro and In Vivo Antiviral Effects against Flavivirus Infections by Targeting the Viral RdRp
por: Wang, Zhuang, et al.
Publicado: (2022)

A hypothesis on designing strategy of effective RdRp inhibitors for the treatment of SARS-CoV-2
por: Chaube, Udit, et al.
Publicado: (2022)

Design, Synthesis, Evaluation and Molecular Dynamics Simulation of Dengue Virus NS5-RdRp Inhibitors
por: Zong, Keli, et al.
Publicado: (2023)

A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro
por: Zhang, Haiping, et al.
Publicado: (2020)

RNA‐dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID‐19
por: Machitani, Mitsuhiro, et al.
Publicado: (2020)

SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study
por: Ahmad, Jamshaid, et al.
Publicado: (2020)

Different selection dynamics of S and RdRp between SARS-CoV-2 genomes with and without the dominant mutations
por: Koçhan, Necla, et al.
Publicado: (2021)

Real-time PCR Ct value in SARS-CoV-2 detection: RdRp or N gene?
por: Abbasi, Hamidreza, et al.
Publicado: (2021)

Hybridization chain reaction circuit-based electrochemiluminescent biosensor for SARS-cov-2 RdRp gene assay
por: Zhang, Kai, et al.
Publicado: (2022)

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors
por: Gao, Shenghua, et al.
Publicado: (2022)

Composition of naturally occurring compounds decreases activity of Omicron and SARS-CoV-2 RdRp complex
por: Goc, Anna, et al.
Publicado: (2022)

RdRp-scan: A bioinformatic resource to identify and annotate divergent RNA viruses in metagenomic sequence data
por: Charon, Justine, et al.
Publicado: (2022)

Antiviral effects of the fused tricyclic derivatives of indoline and imidazolidinone on ZIKV infection and RdRp activities of ZIKV and DENV
por: Zhou, Guang-Feng, et al.
Publicado: (2023)

Design, synthesis, docking, and biochemical characterization of non-nucleoside SARS-CoV-2 RdRp inhibitors
por: Brindani, Nicoletta, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_v85m8ov1qvbr03ak0agakkcoj8