Discovery of Anilino-1,4-naphthoquinones as Potent EGFR Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Comprehensive Molecular Modeling

[Image: see text] Epidermal growth factor receptor (EGFR) has been recognized as one of the attractive targets for anticancer drug development. Herein, a set of anilino-1,4-naphthoquinone derivatives (3–18) was synthesized and investigated for their anticancer and EGFR inhibitory potentials. Among a...

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Detalles Bibliográficos
Autores principales: Mahalapbutr, Panupong, Leechaisit, Ronnakorn, Thongnum, Anusit, Todsaporn, Duangjai, Prachayasittikul, Veda, Rungrotmongkol, Thanyada, Prachayasittikul, Supaluk, Ruchirawat, Somsak, Prachayasittikul, Virapong, Pingaew, Ratchanok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161259/
https://www.ncbi.nlm.nih.gov/pubmed/35664590
http://dx.doi.org/10.1021/acsomega.2c01188

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