The Contribution of HCN Channelopathies in Different Epileptic Syndromes, Mechanisms, Modulators, and Potential Treatment Targets: A Systematic Review

BACKGROUND: Hyperpolarization-activated cyclic nucleotide-gated (HCN) current reduces dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA-mediated postsynaptic potentials, thereby suppressing epilepsy. However, it is unclear whether increased HCN current can produce...

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Detalles Bibliográficos
Autores principales: Kessi, Miriam, Peng, Jing, Duan, Haolin, He, Hailan, Chen, Baiyu, Xiong, Juan, Wang, Ying, Yang, Lifen, Wang, Guoli, Kiprotich, Karlmax, Bamgbade, Olumuyiwa A., He, Fang, Yin, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161305/
https://www.ncbi.nlm.nih.gov/pubmed/35663267
http://dx.doi.org/10.3389/fnmol.2022.807202

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