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Efficacy of first‐line immune checkpoint inhibitors in patients with advanced NSCLC with KRAS , MET , FGFR , RET , BRAF , and HER2 alterations
BACKGROUND: In patients with non‐small cell lung cancer (NSCLC) harboring driver alterations, the efficacy of immune checkpoint inhibitors (ICIs) remains uncertain. Our study aimed to examine the first‐line ICI efficacy in patients with NSCLC harboring KRAS, MET, FGFR, RET, BRAF, and HER2 alteration...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161348/ https://www.ncbi.nlm.nih.gov/pubmed/35491960 http://dx.doi.org/10.1111/1759-7714.14448 |
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author | Uehara, Yuji Watanabe, Kageaki Hakozaki, Taiki Yomota, Makiko Hosomi, Yukio |
author_facet | Uehara, Yuji Watanabe, Kageaki Hakozaki, Taiki Yomota, Makiko Hosomi, Yukio |
author_sort | Uehara, Yuji |
collection | PubMed |
description | BACKGROUND: In patients with non‐small cell lung cancer (NSCLC) harboring driver alterations, the efficacy of immune checkpoint inhibitors (ICIs) remains uncertain. Our study aimed to examine the first‐line ICI efficacy in patients with NSCLC harboring KRAS, MET, FGFR, RET, BRAF, and HER2 alterations in a real‐world setting. METHODS: This single‐center, retrospective cohort study included patients with advanced NSCLC harboring KRAS, MET, FGFR, RET, BRAF, HER2 alterations or driver‐negative, and were treated with first‐line ICI therapy. Best overall response, progression‐free survival (PFS), and overall survival (OS) were evaluated. RESULTS: Seventy‐eight patients with NSCLC were included (median age, 72 years): 67% were men, 15% were never‐smokers, and 83% had adenocarcinoma. The driver alterations involved KRAS (n = 21), MET (n = 6), FGFR (n = 3), RET (n = 2), BRAF (n = 2), HER2 (n = 1), and driver‐negative (n = 43). The partial responses for KRAS, MET, FGFR, RET, BRAF, HER2, and driver‐negative were 57%, 50%, 100%, 50%, 100%, 0%, and 47%, respectively. The median PFS (months) was 16.2 (95% confidence interval [CI]: 6.3– not reached [NR]) for KRAS, 2.8 (95% CI: 2.7–NR) for MET, 11.7 (95% CI: 5.9–NR) for other alterations (FGFR, RET, BRAF, and HER2), and 10.0 (95% CI: 3.7–14.3) for driver‐negative, respectively. The median OS (months) was 31.3 (95% CI: 9.0–NR) for KRAS, not reached for MET, 23.5 (95% CI: 18.3–NR) for other alterations, and 21.1 (95% CI: 15.2–NR) for driver‐negative, respectively. CONCLUSIONS: The benefit of the first‐line ICI was similar in advanced NSCLC regardless of the driver alterations, except for MET alterations. |
format | Online Article Text |
id | pubmed-9161348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-91613482022-06-04 Efficacy of first‐line immune checkpoint inhibitors in patients with advanced NSCLC with KRAS , MET , FGFR , RET , BRAF , and HER2 alterations Uehara, Yuji Watanabe, Kageaki Hakozaki, Taiki Yomota, Makiko Hosomi, Yukio Thorac Cancer Original Articles BACKGROUND: In patients with non‐small cell lung cancer (NSCLC) harboring driver alterations, the efficacy of immune checkpoint inhibitors (ICIs) remains uncertain. Our study aimed to examine the first‐line ICI efficacy in patients with NSCLC harboring KRAS, MET, FGFR, RET, BRAF, and HER2 alterations in a real‐world setting. METHODS: This single‐center, retrospective cohort study included patients with advanced NSCLC harboring KRAS, MET, FGFR, RET, BRAF, HER2 alterations or driver‐negative, and were treated with first‐line ICI therapy. Best overall response, progression‐free survival (PFS), and overall survival (OS) were evaluated. RESULTS: Seventy‐eight patients with NSCLC were included (median age, 72 years): 67% were men, 15% were never‐smokers, and 83% had adenocarcinoma. The driver alterations involved KRAS (n = 21), MET (n = 6), FGFR (n = 3), RET (n = 2), BRAF (n = 2), HER2 (n = 1), and driver‐negative (n = 43). The partial responses for KRAS, MET, FGFR, RET, BRAF, HER2, and driver‐negative were 57%, 50%, 100%, 50%, 100%, 0%, and 47%, respectively. The median PFS (months) was 16.2 (95% confidence interval [CI]: 6.3– not reached [NR]) for KRAS, 2.8 (95% CI: 2.7–NR) for MET, 11.7 (95% CI: 5.9–NR) for other alterations (FGFR, RET, BRAF, and HER2), and 10.0 (95% CI: 3.7–14.3) for driver‐negative, respectively. The median OS (months) was 31.3 (95% CI: 9.0–NR) for KRAS, not reached for MET, 23.5 (95% CI: 18.3–NR) for other alterations, and 21.1 (95% CI: 15.2–NR) for driver‐negative, respectively. CONCLUSIONS: The benefit of the first‐line ICI was similar in advanced NSCLC regardless of the driver alterations, except for MET alterations. John Wiley & Sons Australia, Ltd 2022-05-02 2022-06 /pmc/articles/PMC9161348/ /pubmed/35491960 http://dx.doi.org/10.1111/1759-7714.14448 Text en © 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Uehara, Yuji Watanabe, Kageaki Hakozaki, Taiki Yomota, Makiko Hosomi, Yukio Efficacy of first‐line immune checkpoint inhibitors in patients with advanced NSCLC with KRAS , MET , FGFR , RET , BRAF , and HER2 alterations |
title | Efficacy of first‐line immune checkpoint inhibitors in patients with advanced NSCLC with
KRAS
,
MET
,
FGFR
,
RET
,
BRAF
, and
HER2
alterations |
title_full | Efficacy of first‐line immune checkpoint inhibitors in patients with advanced NSCLC with
KRAS
,
MET
,
FGFR
,
RET
,
BRAF
, and
HER2
alterations |
title_fullStr | Efficacy of first‐line immune checkpoint inhibitors in patients with advanced NSCLC with
KRAS
,
MET
,
FGFR
,
RET
,
BRAF
, and
HER2
alterations |
title_full_unstemmed | Efficacy of first‐line immune checkpoint inhibitors in patients with advanced NSCLC with
KRAS
,
MET
,
FGFR
,
RET
,
BRAF
, and
HER2
alterations |
title_short | Efficacy of first‐line immune checkpoint inhibitors in patients with advanced NSCLC with
KRAS
,
MET
,
FGFR
,
RET
,
BRAF
, and
HER2
alterations |
title_sort | efficacy of first‐line immune checkpoint inhibitors in patients with advanced nsclc with
kras
,
met
,
fgfr
,
ret
,
braf
, and
her2
alterations |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161348/ https://www.ncbi.nlm.nih.gov/pubmed/35491960 http://dx.doi.org/10.1111/1759-7714.14448 |
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