The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus driving the ongoing coronavirus disease 2019 (COVID-19) pandemic, continues to rapidly evolve. Due to the limited efficacy of vaccination in prevention of SARS-CoV-2 transmission and continuous emergence of variants of concern (...

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Detalles Bibliográficos
Autores principales: Cao, Liu, Li, Yingjun, Yang, Sidi, Li, Guanguan, Zhou, Qifan, Sun, Jing, Xu, Tiefeng, Yang, Yang, Liao, Ruyan, Shi, Yongxia, Yang, Yujian, Zhu, Tiaozhen, Huang, Siyao, Ji, Yanxi, Cong, Feng, Luo, Yinzhu, Zhu, Yujun, Luan, Hemi, Zhang, Huan, Chen, Jingdiao, Liu, Xue, Luo, Renru, Liu, Lihong, Wang, Ping, Yu, Yang, Xing, Fan, Ke, Bixia, Zheng, Huanying, Deng, Xiaoling, Zhang, Wenyong, Lin, Chuwen, Shi, Mang, Li, Chun-Mei, Zhang, Yu, Zhang, Lu, Dai, Jun, Lu, Hongzhou, Zhao, Jincun, Zhang, Xumu, Guo, Deyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161374/
https://www.ncbi.nlm.nih.gov/pubmed/35579533
http://dx.doi.org/10.1126/scitranslmed.abm7621

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