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Open-Form Configurational Isomers of a Tricyanofuran-Type Metastable-State Photoacid

[Image: see text] We determine the presence of four open-form configurational isomers for an unsubstituted metastable-state photoacid (mPAH) of the tricyanofuran (TCF) type in solution, at room temperature, via 2D NMR experiments. Electronic structure calculations are carried out to predict the rela...

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Detalles Bibliográficos
Autores principales: Arias, Juan E., Richardson, David, Romero, Eduardo E., Abdelrahim, Mohamed, Patel, Parth K., Hernandez, Florencio E., Chumbimuni-Torres, Karin Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161401/
https://www.ncbi.nlm.nih.gov/pubmed/35664574
http://dx.doi.org/10.1021/acsomega.1c06623
Descripción
Sumario:[Image: see text] We determine the presence of four open-form configurational isomers for an unsubstituted metastable-state photoacid (mPAH) of the tricyanofuran (TCF) type in solution, at room temperature, via 2D NMR experiments. Electronic structure calculations are carried out to predict the relative stability of the isomers found experimentally and their isomerization barriers. According to the calculated rate constants for isomerization, the molecule can freely interconvert between the open-form isomers, thereby providing a thermal pathway between the isomers that might be better suited to access the cyclized closed-form configuration and those that are not. In establishing the open form isomeric makeup of the TCF mPAH under study, this work establishes the need to consider the four isomers in further studies on the thermal and excited-state isomerization processes and substituent effect thereon.