Functionalization of Tetrazoles Bearing the Electrochemically Cleavable 1N-(6-Methylpyridyl-2-methyl) Protecting Group

[Image: see text] 6-Methylpyridyl-2-methyl protected tetrazoles can be C–H deprotonated using the turbo-Grignard reagent and involved in the reactions with aldehydes and ketones. The protecting group can be cleaved under reductive electrochemical conditions using Pb bronze as a cathode and Zn as a s...

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Detalles Bibliográficos
Autores principales: Grammatoglou, Konstantinos, Da̅rziņa, Madara, Jirgensons, Aigars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161418/
https://www.ncbi.nlm.nih.gov/pubmed/35664598
http://dx.doi.org/10.1021/acsomega.2c01633
Descripción
Sumario:[Image: see text] 6-Methylpyridyl-2-methyl protected tetrazoles can be C–H deprotonated using the turbo-Grignard reagent and involved in the reactions with aldehydes and ketones. The protecting group can be cleaved under reductive electrochemical conditions using Pb bronze as a cathode and Zn as a sacrificial anode.

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