Functionalization of Tetrazoles Bearing the Electrochemically Cleavable 1N-(6-Methylpyridyl-2-methyl) Protecting Group

[Image: see text] 6-Methylpyridyl-2-methyl protected tetrazoles can be C–H deprotonated using the turbo-Grignard reagent and involved in the reactions with aldehydes and ketones. The protecting group can be cleaved under reductive electrochemical conditions using Pb bronze as a cathode and Zn as a s...

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Autores principales: Grammatoglou, Konstantinos, Da̅rziņa, Madara, Jirgensons, Aigars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161418/
https://www.ncbi.nlm.nih.gov/pubmed/35664598
http://dx.doi.org/10.1021/acsomega.2c01633
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author Grammatoglou, Konstantinos
Da̅rziņa, Madara
Jirgensons, Aigars
author_facet Grammatoglou, Konstantinos
Da̅rziņa, Madara
Jirgensons, Aigars
author_sort Grammatoglou, Konstantinos
collection PubMed
description [Image: see text] 6-Methylpyridyl-2-methyl protected tetrazoles can be C–H deprotonated using the turbo-Grignard reagent and involved in the reactions with aldehydes and ketones. The protecting group can be cleaved under reductive electrochemical conditions using Pb bronze as a cathode and Zn as a sacrificial anode.
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spelling pubmed-91614182022-06-03 Functionalization of Tetrazoles Bearing the Electrochemically Cleavable 1N-(6-Methylpyridyl-2-methyl) Protecting Group Grammatoglou, Konstantinos Da̅rziņa, Madara Jirgensons, Aigars ACS Omega [Image: see text] 6-Methylpyridyl-2-methyl protected tetrazoles can be C–H deprotonated using the turbo-Grignard reagent and involved in the reactions with aldehydes and ketones. The protecting group can be cleaved under reductive electrochemical conditions using Pb bronze as a cathode and Zn as a sacrificial anode. American Chemical Society 2022-05-16 /pmc/articles/PMC9161418/ /pubmed/35664598 http://dx.doi.org/10.1021/acsomega.2c01633 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Grammatoglou, Konstantinos
Da̅rziņa, Madara
Jirgensons, Aigars
Functionalization of Tetrazoles Bearing the Electrochemically Cleavable 1N-(6-Methylpyridyl-2-methyl) Protecting Group
title Functionalization of Tetrazoles Bearing the Electrochemically Cleavable 1N-(6-Methylpyridyl-2-methyl) Protecting Group
title_full Functionalization of Tetrazoles Bearing the Electrochemically Cleavable 1N-(6-Methylpyridyl-2-methyl) Protecting Group
title_fullStr Functionalization of Tetrazoles Bearing the Electrochemically Cleavable 1N-(6-Methylpyridyl-2-methyl) Protecting Group
title_full_unstemmed Functionalization of Tetrazoles Bearing the Electrochemically Cleavable 1N-(6-Methylpyridyl-2-methyl) Protecting Group
title_short Functionalization of Tetrazoles Bearing the Electrochemically Cleavable 1N-(6-Methylpyridyl-2-methyl) Protecting Group
title_sort functionalization of tetrazoles bearing the electrochemically cleavable 1n-(6-methylpyridyl-2-methyl) protecting group
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161418/
https://www.ncbi.nlm.nih.gov/pubmed/35664598
http://dx.doi.org/10.1021/acsomega.2c01633
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AT jirgensonsaigars functionalizationoftetrazolesbearingtheelectrochemicallycleavable1n6methylpyridyl2methylprotectinggroup

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