5’isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1

BACKGROUND: MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in different target spectra and thereby extending the phenotypic impact of the respective...

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Detalles Bibliográficos
Autores principales: Li, Xiaoya, Michels, Birgitta Elisabeth, Tosun, Oyku Ece, Jung, Janine, Kappes, Jolane, Ibing, Susanne, Nataraj, Nishanth Belugali, Sahay, Shashwat, Schneider, Martin, Wörner, Angelika, Becki, Corinna, Ishaque, Naveed, Feuerbach, Lars, Heßling, Bernd, Helm, Dominic, Will, Rainer, Yarden, Yosef, Müller-Decker, Karin, Wiemann, Stefan, Körner, Cindy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161486/
https://www.ncbi.nlm.nih.gov/pubmed/35655310
http://dx.doi.org/10.1186/s13046-022-02380-8

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