Cargando…

Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience

RATIONALE: Transbronchial cryobiopsy has been increasingly used to diagnose interstitial lung diseases. However, there is uncertainty regarding its accuracy and risks, mainly due to a paucity of prospective or randomized trials comparing cryobiopsy to surgical biopsy. OBJECTIVES: To evaluate the dia...

Descripción completa

Detalles Bibliográficos
Autores principales: Ribeiro Neto, Manuel L., Arrossi, Andrea Valeria, Yadav, Ruchi, Culver, Daniel A., Mukhopadhyay, Sanjay, Parambil, Joseph G., Southern, Brian D., Tolle, Leslie, Pande, Aman, Almeida, Francisco A., Sahoo, Debasis, Glennie, Jessica, Ahmad, Usman, Mehta, Atul C., Gildea, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161499/
https://www.ncbi.nlm.nih.gov/pubmed/35655191
http://dx.doi.org/10.1186/s12890-022-01990-4
_version_ 1784719498027204608
author Ribeiro Neto, Manuel L.
Arrossi, Andrea Valeria
Yadav, Ruchi
Culver, Daniel A.
Mukhopadhyay, Sanjay
Parambil, Joseph G.
Southern, Brian D.
Tolle, Leslie
Pande, Aman
Almeida, Francisco A.
Sahoo, Debasis
Glennie, Jessica
Ahmad, Usman
Mehta, Atul C.
Gildea, Thomas R.
author_facet Ribeiro Neto, Manuel L.
Arrossi, Andrea Valeria
Yadav, Ruchi
Culver, Daniel A.
Mukhopadhyay, Sanjay
Parambil, Joseph G.
Southern, Brian D.
Tolle, Leslie
Pande, Aman
Almeida, Francisco A.
Sahoo, Debasis
Glennie, Jessica
Ahmad, Usman
Mehta, Atul C.
Gildea, Thomas R.
author_sort Ribeiro Neto, Manuel L.
collection PubMed
description RATIONALE: Transbronchial cryobiopsy has been increasingly used to diagnose interstitial lung diseases. However, there is uncertainty regarding its accuracy and risks, mainly due to a paucity of prospective or randomized trials comparing cryobiopsy to surgical biopsy. OBJECTIVES: To evaluate the diagnostic yield and complications of cryobiopsy in patients selected by multidisciplinary discussion. METHODS: This was a prospective cohort from 2017 to 2019. We included consecutive patients with suspected interstitial lung diseases being considered for lung biopsy presented at our multidisciplinary meeting. MEASUREMENTS AND MAIN RESULTS: Of 112 patients, we recommended no biopsy in 31, transbronchial forceps biopsy in 16, cryobiopsy in 54 and surgical biopsy in 11. By the end of the study, 34 patients had had cryobiopsy and 24 patients, surgical biopsy. Overall pathologic and multidisciplinary diagnostic yield of cryobiopsy was 47.1% and 61.8%, respectively. The yield increased over time for both pathologic (year 1: 28.6%, year 2: 54.5%, year 3: 66.7%, p = 0.161) and multidisciplinary (year 1: 50%, year 2: 63.6%, year 3: 77.8%, p = 0.412) diagnosis. Overall rate of grade 4 bleeding after cryobiopsy was 11.8%. Cryobiopsy required less chest tube placement (11.8% vs 100%, p < 0.001) and less hospitalizations compared to surgical biopsy (26.5% vs 95.7%, p < 0.001), but hospitalized patients had a longer median hospital stay (2 days vs 1 day, p = 0.004). CONCLUSIONS: Diagnostic yield of cryobiopsy increased over time but the overall grade 4 bleeding rate was 11.8%. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-01990-4.
format Online
Article
Text
id pubmed-9161499
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-91614992022-06-03 Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience Ribeiro Neto, Manuel L. Arrossi, Andrea Valeria Yadav, Ruchi Culver, Daniel A. Mukhopadhyay, Sanjay Parambil, Joseph G. Southern, Brian D. Tolle, Leslie Pande, Aman Almeida, Francisco A. Sahoo, Debasis Glennie, Jessica Ahmad, Usman Mehta, Atul C. Gildea, Thomas R. BMC Pulm Med Research RATIONALE: Transbronchial cryobiopsy has been increasingly used to diagnose interstitial lung diseases. However, there is uncertainty regarding its accuracy and risks, mainly due to a paucity of prospective or randomized trials comparing cryobiopsy to surgical biopsy. OBJECTIVES: To evaluate the diagnostic yield and complications of cryobiopsy in patients selected by multidisciplinary discussion. METHODS: This was a prospective cohort from 2017 to 2019. We included consecutive patients with suspected interstitial lung diseases being considered for lung biopsy presented at our multidisciplinary meeting. MEASUREMENTS AND MAIN RESULTS: Of 112 patients, we recommended no biopsy in 31, transbronchial forceps biopsy in 16, cryobiopsy in 54 and surgical biopsy in 11. By the end of the study, 34 patients had had cryobiopsy and 24 patients, surgical biopsy. Overall pathologic and multidisciplinary diagnostic yield of cryobiopsy was 47.1% and 61.8%, respectively. The yield increased over time for both pathologic (year 1: 28.6%, year 2: 54.5%, year 3: 66.7%, p = 0.161) and multidisciplinary (year 1: 50%, year 2: 63.6%, year 3: 77.8%, p = 0.412) diagnosis. Overall rate of grade 4 bleeding after cryobiopsy was 11.8%. Cryobiopsy required less chest tube placement (11.8% vs 100%, p < 0.001) and less hospitalizations compared to surgical biopsy (26.5% vs 95.7%, p < 0.001), but hospitalized patients had a longer median hospital stay (2 days vs 1 day, p = 0.004). CONCLUSIONS: Diagnostic yield of cryobiopsy increased over time but the overall grade 4 bleeding rate was 11.8%. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-01990-4. BioMed Central 2022-06-02 /pmc/articles/PMC9161499/ /pubmed/35655191 http://dx.doi.org/10.1186/s12890-022-01990-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Ribeiro Neto, Manuel L.
Arrossi, Andrea Valeria
Yadav, Ruchi
Culver, Daniel A.
Mukhopadhyay, Sanjay
Parambil, Joseph G.
Southern, Brian D.
Tolle, Leslie
Pande, Aman
Almeida, Francisco A.
Sahoo, Debasis
Glennie, Jessica
Ahmad, Usman
Mehta, Atul C.
Gildea, Thomas R.
Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience
title Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience
title_full Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience
title_fullStr Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience
title_full_unstemmed Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience
title_short Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience
title_sort prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161499/
https://www.ncbi.nlm.nih.gov/pubmed/35655191
http://dx.doi.org/10.1186/s12890-022-01990-4
work_keys_str_mv AT ribeironetomanuell prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT arrossiandreavaleria prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT yadavruchi prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT culverdaniela prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT mukhopadhyaysanjay prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT parambiljosephg prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT southernbriand prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT tolleleslie prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT pandeaman prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT almeidafranciscoa prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT sahoodebasis prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT glenniejessica prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT ahmadusman prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT mehtaatulc prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience
AT gildeathomasr prospectivecohortofcryobiopsyininterstitiallungdiseasesasinglecenterexperience