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Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience
RATIONALE: Transbronchial cryobiopsy has been increasingly used to diagnose interstitial lung diseases. However, there is uncertainty regarding its accuracy and risks, mainly due to a paucity of prospective or randomized trials comparing cryobiopsy to surgical biopsy. OBJECTIVES: To evaluate the dia...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161499/ https://www.ncbi.nlm.nih.gov/pubmed/35655191 http://dx.doi.org/10.1186/s12890-022-01990-4 |
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author | Ribeiro Neto, Manuel L. Arrossi, Andrea Valeria Yadav, Ruchi Culver, Daniel A. Mukhopadhyay, Sanjay Parambil, Joseph G. Southern, Brian D. Tolle, Leslie Pande, Aman Almeida, Francisco A. Sahoo, Debasis Glennie, Jessica Ahmad, Usman Mehta, Atul C. Gildea, Thomas R. |
author_facet | Ribeiro Neto, Manuel L. Arrossi, Andrea Valeria Yadav, Ruchi Culver, Daniel A. Mukhopadhyay, Sanjay Parambil, Joseph G. Southern, Brian D. Tolle, Leslie Pande, Aman Almeida, Francisco A. Sahoo, Debasis Glennie, Jessica Ahmad, Usman Mehta, Atul C. Gildea, Thomas R. |
author_sort | Ribeiro Neto, Manuel L. |
collection | PubMed |
description | RATIONALE: Transbronchial cryobiopsy has been increasingly used to diagnose interstitial lung diseases. However, there is uncertainty regarding its accuracy and risks, mainly due to a paucity of prospective or randomized trials comparing cryobiopsy to surgical biopsy. OBJECTIVES: To evaluate the diagnostic yield and complications of cryobiopsy in patients selected by multidisciplinary discussion. METHODS: This was a prospective cohort from 2017 to 2019. We included consecutive patients with suspected interstitial lung diseases being considered for lung biopsy presented at our multidisciplinary meeting. MEASUREMENTS AND MAIN RESULTS: Of 112 patients, we recommended no biopsy in 31, transbronchial forceps biopsy in 16, cryobiopsy in 54 and surgical biopsy in 11. By the end of the study, 34 patients had had cryobiopsy and 24 patients, surgical biopsy. Overall pathologic and multidisciplinary diagnostic yield of cryobiopsy was 47.1% and 61.8%, respectively. The yield increased over time for both pathologic (year 1: 28.6%, year 2: 54.5%, year 3: 66.7%, p = 0.161) and multidisciplinary (year 1: 50%, year 2: 63.6%, year 3: 77.8%, p = 0.412) diagnosis. Overall rate of grade 4 bleeding after cryobiopsy was 11.8%. Cryobiopsy required less chest tube placement (11.8% vs 100%, p < 0.001) and less hospitalizations compared to surgical biopsy (26.5% vs 95.7%, p < 0.001), but hospitalized patients had a longer median hospital stay (2 days vs 1 day, p = 0.004). CONCLUSIONS: Diagnostic yield of cryobiopsy increased over time but the overall grade 4 bleeding rate was 11.8%. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-01990-4. |
format | Online Article Text |
id | pubmed-9161499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91614992022-06-03 Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience Ribeiro Neto, Manuel L. Arrossi, Andrea Valeria Yadav, Ruchi Culver, Daniel A. Mukhopadhyay, Sanjay Parambil, Joseph G. Southern, Brian D. Tolle, Leslie Pande, Aman Almeida, Francisco A. Sahoo, Debasis Glennie, Jessica Ahmad, Usman Mehta, Atul C. Gildea, Thomas R. BMC Pulm Med Research RATIONALE: Transbronchial cryobiopsy has been increasingly used to diagnose interstitial lung diseases. However, there is uncertainty regarding its accuracy and risks, mainly due to a paucity of prospective or randomized trials comparing cryobiopsy to surgical biopsy. OBJECTIVES: To evaluate the diagnostic yield and complications of cryobiopsy in patients selected by multidisciplinary discussion. METHODS: This was a prospective cohort from 2017 to 2019. We included consecutive patients with suspected interstitial lung diseases being considered for lung biopsy presented at our multidisciplinary meeting. MEASUREMENTS AND MAIN RESULTS: Of 112 patients, we recommended no biopsy in 31, transbronchial forceps biopsy in 16, cryobiopsy in 54 and surgical biopsy in 11. By the end of the study, 34 patients had had cryobiopsy and 24 patients, surgical biopsy. Overall pathologic and multidisciplinary diagnostic yield of cryobiopsy was 47.1% and 61.8%, respectively. The yield increased over time for both pathologic (year 1: 28.6%, year 2: 54.5%, year 3: 66.7%, p = 0.161) and multidisciplinary (year 1: 50%, year 2: 63.6%, year 3: 77.8%, p = 0.412) diagnosis. Overall rate of grade 4 bleeding after cryobiopsy was 11.8%. Cryobiopsy required less chest tube placement (11.8% vs 100%, p < 0.001) and less hospitalizations compared to surgical biopsy (26.5% vs 95.7%, p < 0.001), but hospitalized patients had a longer median hospital stay (2 days vs 1 day, p = 0.004). CONCLUSIONS: Diagnostic yield of cryobiopsy increased over time but the overall grade 4 bleeding rate was 11.8%. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-01990-4. BioMed Central 2022-06-02 /pmc/articles/PMC9161499/ /pubmed/35655191 http://dx.doi.org/10.1186/s12890-022-01990-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Ribeiro Neto, Manuel L. Arrossi, Andrea Valeria Yadav, Ruchi Culver, Daniel A. Mukhopadhyay, Sanjay Parambil, Joseph G. Southern, Brian D. Tolle, Leslie Pande, Aman Almeida, Francisco A. Sahoo, Debasis Glennie, Jessica Ahmad, Usman Mehta, Atul C. Gildea, Thomas R. Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience |
title | Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience |
title_full | Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience |
title_fullStr | Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience |
title_full_unstemmed | Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience |
title_short | Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience |
title_sort | prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161499/ https://www.ncbi.nlm.nih.gov/pubmed/35655191 http://dx.doi.org/10.1186/s12890-022-01990-4 |
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