Biphasic synovial sarcomas of the liver: a case report and literature review

BACKGROUND: Synovial sarcoma is a soft tissue sarcoma of temporarily unknown histologic origin with the ability for biphasic differentiation, occurring mostly in the vicinity of large joints of the extremities. Synovial sarcoma that originates in the liver is extremely rare. Only 7 cases have been r...

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Autores principales: Liang, Defeng, Meng, Lingyu, Wang, Shanshan, Yi, Dan, Liu, Yahui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161578/
https://www.ncbi.nlm.nih.gov/pubmed/35655305
http://dx.doi.org/10.1186/s13000-022-01233-4
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author Liang, Defeng
Meng, Lingyu
Wang, Shanshan
Yi, Dan
Liu, Yahui
author_facet Liang, Defeng
Meng, Lingyu
Wang, Shanshan
Yi, Dan
Liu, Yahui
author_sort Liang, Defeng
collection PubMed
description BACKGROUND: Synovial sarcoma is a soft tissue sarcoma of temporarily unknown histologic origin with the ability for biphasic differentiation, occurring mostly in the vicinity of large joints of the extremities. Synovial sarcoma that originates in the liver is extremely rare. Only 7 cases have been reported in the domestic and international literature. CASE PRESENTATION: We report an 11-year-old female patient who underwent partial hepatectomy for a liver mass. Microscopically, she was diagnosed with hepatic biphasic synovial sarcoma. Cytogenetic examination revealed the fusion gene SS18-SSX1 (+), which confirmed the diagnosis. CONCLUSION: Synovial sarcoma of the liver is a rare malignancy that is difficult to diagnose. Confirmation of diagnosis is based on histopathological assessment combined with immunohistochemical staining and, if necessary, cytogenetic aids. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13000-022-01233-4.
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spelling pubmed-91615782022-06-03 Biphasic synovial sarcomas of the liver: a case report and literature review Liang, Defeng Meng, Lingyu Wang, Shanshan Yi, Dan Liu, Yahui Diagn Pathol Case Report BACKGROUND: Synovial sarcoma is a soft tissue sarcoma of temporarily unknown histologic origin with the ability for biphasic differentiation, occurring mostly in the vicinity of large joints of the extremities. Synovial sarcoma that originates in the liver is extremely rare. Only 7 cases have been reported in the domestic and international literature. CASE PRESENTATION: We report an 11-year-old female patient who underwent partial hepatectomy for a liver mass. Microscopically, she was diagnosed with hepatic biphasic synovial sarcoma. Cytogenetic examination revealed the fusion gene SS18-SSX1 (+), which confirmed the diagnosis. CONCLUSION: Synovial sarcoma of the liver is a rare malignancy that is difficult to diagnose. Confirmation of diagnosis is based on histopathological assessment combined with immunohistochemical staining and, if necessary, cytogenetic aids. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13000-022-01233-4. BioMed Central 2022-06-02 /pmc/articles/PMC9161578/ /pubmed/35655305 http://dx.doi.org/10.1186/s13000-022-01233-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Liang, Defeng
Meng, Lingyu
Wang, Shanshan
Yi, Dan
Liu, Yahui
Biphasic synovial sarcomas of the liver: a case report and literature review
title Biphasic synovial sarcomas of the liver: a case report and literature review
title_full Biphasic synovial sarcomas of the liver: a case report and literature review
title_fullStr Biphasic synovial sarcomas of the liver: a case report and literature review
title_full_unstemmed Biphasic synovial sarcomas of the liver: a case report and literature review
title_short Biphasic synovial sarcomas of the liver: a case report and literature review
title_sort biphasic synovial sarcomas of the liver: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161578/
https://www.ncbi.nlm.nih.gov/pubmed/35655305
http://dx.doi.org/10.1186/s13000-022-01233-4
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AT wangshanshan biphasicsynovialsarcomasoftheliveracasereportandliteraturereview
AT yidan biphasicsynovialsarcomasoftheliveracasereportandliteraturereview
AT liuyahui biphasicsynovialsarcomasoftheliveracasereportandliteraturereview

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