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Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis
BACKGROUND: Epigenetic changes, especially DNA methylation have a main role in regulating cardiometabolic disorders and their risk factors. This study provides a review of the current evidence on the association between methylation of some genes (LINE1, ABCG1, SREBF1, PHOSPHO1, ADRB3, and LEP) and c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161587/ https://www.ncbi.nlm.nih.gov/pubmed/35655232 http://dx.doi.org/10.1186/s13690-022-00907-1 |
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author | Barouti, Zahra Heidari-Beni, Motahar Shabanian-Boroujeni, Anahita Mohammadzadeh, Morteza Pahlevani, Vida Poursafa, Parnian Mohebpour, Fatemeh Kelishadi, Roya |
author_facet | Barouti, Zahra Heidari-Beni, Motahar Shabanian-Boroujeni, Anahita Mohammadzadeh, Morteza Pahlevani, Vida Poursafa, Parnian Mohebpour, Fatemeh Kelishadi, Roya |
author_sort | Barouti, Zahra |
collection | PubMed |
description | BACKGROUND: Epigenetic changes, especially DNA methylation have a main role in regulating cardiometabolic disorders and their risk factors. This study provides a review of the current evidence on the association between methylation of some genes (LINE1, ABCG1, SREBF1, PHOSPHO1, ADRB3, and LEP) and cardiometabolic risk factors. METHODS: A systematic literature search was conducted in electronic databases including Web of Science, PubMed, EMBASE, Google Scholar and Scopus up to end of 2020. All observational human studies (cross-sectional, case–control, and cohort) were included. Studies that assessed the effect of DNA methylation on cardiometabolic risk factors were selected. RESULTS: Among 1398 articles, eight studies and twenty-one studies were included in the meta-analysis and the systematic review, respectively. Our study showed ABCG1 and LINE1 methylation were positively associated with blood pressure (Fisher’s zr = 0.07 (0.06, 0.09), 95% CI: 0.05 to 0.08). Methylation in LINE1, ABCG1, SREBF1, PHOSPHO1 and ADRB3 had no significant association with HDL levels (Fisher’s zr = − 0.05 (− 0.13, 0.03), 95% CI:-0.12 to 0.02). Positive association was existed between LINE1, ABCG1 and LEP methylation and LDL levels (Fisher’s zr = 0.13 (0.04, 0.23), 95% CI: 0.03 to 0.23). Moreover, positive association was found between HbA1C and ABCG1 methylation (Fisher’s zr = 0.11 (0.09, 0.13), 95% CI: 0.09 to 0.12). DNA methylation of LINE1, ABCG1 and SREBF1 genes had no significant association with glucose levels (Fisher’s zr = 0.01 (− 0.12, 0.14), 95% CI:-0.12 to 0.14). CONCLUSION: This meta-analysis showed that DNA methylation was associated with some cardiometabolic risk factors including LDL-C, HbA1C, and blood pressure. REGISTRATION: Registration ID of the protocol on PROSPERO is CRD42020207677. |
format | Online Article Text |
id | pubmed-9161587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91615872022-06-03 Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis Barouti, Zahra Heidari-Beni, Motahar Shabanian-Boroujeni, Anahita Mohammadzadeh, Morteza Pahlevani, Vida Poursafa, Parnian Mohebpour, Fatemeh Kelishadi, Roya Arch Public Health Systematic Review BACKGROUND: Epigenetic changes, especially DNA methylation have a main role in regulating cardiometabolic disorders and their risk factors. This study provides a review of the current evidence on the association between methylation of some genes (LINE1, ABCG1, SREBF1, PHOSPHO1, ADRB3, and LEP) and cardiometabolic risk factors. METHODS: A systematic literature search was conducted in electronic databases including Web of Science, PubMed, EMBASE, Google Scholar and Scopus up to end of 2020. All observational human studies (cross-sectional, case–control, and cohort) were included. Studies that assessed the effect of DNA methylation on cardiometabolic risk factors were selected. RESULTS: Among 1398 articles, eight studies and twenty-one studies were included in the meta-analysis and the systematic review, respectively. Our study showed ABCG1 and LINE1 methylation were positively associated with blood pressure (Fisher’s zr = 0.07 (0.06, 0.09), 95% CI: 0.05 to 0.08). Methylation in LINE1, ABCG1, SREBF1, PHOSPHO1 and ADRB3 had no significant association with HDL levels (Fisher’s zr = − 0.05 (− 0.13, 0.03), 95% CI:-0.12 to 0.02). Positive association was existed between LINE1, ABCG1 and LEP methylation and LDL levels (Fisher’s zr = 0.13 (0.04, 0.23), 95% CI: 0.03 to 0.23). Moreover, positive association was found between HbA1C and ABCG1 methylation (Fisher’s zr = 0.11 (0.09, 0.13), 95% CI: 0.09 to 0.12). DNA methylation of LINE1, ABCG1 and SREBF1 genes had no significant association with glucose levels (Fisher’s zr = 0.01 (− 0.12, 0.14), 95% CI:-0.12 to 0.14). CONCLUSION: This meta-analysis showed that DNA methylation was associated with some cardiometabolic risk factors including LDL-C, HbA1C, and blood pressure. REGISTRATION: Registration ID of the protocol on PROSPERO is CRD42020207677. BioMed Central 2022-06-02 /pmc/articles/PMC9161587/ /pubmed/35655232 http://dx.doi.org/10.1186/s13690-022-00907-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Systematic Review Barouti, Zahra Heidari-Beni, Motahar Shabanian-Boroujeni, Anahita Mohammadzadeh, Morteza Pahlevani, Vida Poursafa, Parnian Mohebpour, Fatemeh Kelishadi, Roya Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis |
title | Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis |
title_full | Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis |
title_fullStr | Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis |
title_full_unstemmed | Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis |
title_short | Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis |
title_sort | effects of dna methylation on cardiometabolic risk factors: a systematic review and meta-analysis |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161587/ https://www.ncbi.nlm.nih.gov/pubmed/35655232 http://dx.doi.org/10.1186/s13690-022-00907-1 |
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