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Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies

Human blood brain barrier (BBB) models derived from induced pluripotent stem cells (iPSCs) have become an important tool for the discovery and preclinical evaluation of central nervous system (CNS) targeting cell and gene-based therapies. Chimeric antigen receptor (CAR)-T cell therapy is a revolutio...

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Detalles Bibliográficos
Autores principales:	Huang, Jez, Li, Ying Betty, Charlebois, Claudie, Nguyen, Tina, Liu, Ziying, Bloemberg, Darin, Zafer, Ahmed, Baumann, Ewa, Sodja, Caroline, Leclerc, Sonia, Fewell, Gwen, Liu, Qing, Prabhakarpandian, Balabhaskar, McComb, Scott, Stanimirovic, Danica B., Jezierski, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161615/ https://www.ncbi.nlm.nih.gov/pubmed/35650594 http://dx.doi.org/10.1186/s12987-022-00342-y

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