Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current

Voltage-gated sodium (Nav1.5) channels support the genesis and brisk spatial propagation of action potentials in the heart. Disruption of Na(V)1.5 inactivation results in a small persistent Na influx known as late Na current (I(Na,L)), which has emerged as a common pathogenic mechanism in both conge...

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Detalles Bibliográficos
Autores principales: Chakouri, Nourdine, Rivas, Sharen, Roybal, Daniel, Yang, Lin, Diaz, Johanna, Hsu, Allen, Mahling, Ryan, Chen, Bi-Xing, Owoyemi, Josiah O., DiSilvestre, Deborah, Sirabella, Dario, Corneo, Barbara, Tomaselli, Gordon F., Dick, Ivy E., Marx, Steven O., Ben-Johny, Manu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161660/
https://www.ncbi.nlm.nih.gov/pubmed/35662881
http://dx.doi.org/10.1038/s44161-022-00060-6

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