Surface cysteines could protect the SARS-CoV-2 main protease from oxidative damage

The SARS-CoV-2 main protease (M(pro)) is responsible for cleaving twelve nonstructural proteins from the viral polyprotein. M(pro), a cysteine protease, is characterized by a large number of noncatalytic cysteine (Cys) residues, none involved in disulfide bonds. In the absence of a tertiary-structur...

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Detalles Bibliográficos
Autores principales: Ravanfar, Raheleh, Sheng, Yuling, Shahgholi, Mona, Lomenick, Brett, Jones, Jeff, Chou, Tsui-Fen, Gray, Harry B., Winkler, Jay R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161685/
https://www.ncbi.nlm.nih.gov/pubmed/35675741
http://dx.doi.org/10.1016/j.jinorgbio.2022.111886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161685/
https://www.ncbi.nlm.nih.gov/pubmed/35675741
http://dx.doi.org/10.1016/j.jinorgbio.2022.111886

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