Cargando…

Matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression

Matrine exhibits anti-tumor effect on the proliferation and invasion of colorectal cancer (CRC) cells by reducing the activity of the p38 signaling pathway. However, these studies were limited because the underlying mechanism by which matrine inhibited CRC progression remained unclear. In this study...

Descripción completa

Detalles Bibliográficos
Autores principales: Ren, Hongtao, Wang, Yali, Guo, Ya, Wang, Mincong, Ma, Xiulong, Li, Wen, Guo, Yuyan, Li, Yiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161898/
https://www.ncbi.nlm.nih.gov/pubmed/35412433
http://dx.doi.org/10.1080/21655979.2022.2060777
_version_ 1784719580299526144
author Ren, Hongtao
Wang, Yali
Guo, Ya
Wang, Mincong
Ma, Xiulong
Li, Wen
Guo, Yuyan
Li, Yiming
author_facet Ren, Hongtao
Wang, Yali
Guo, Ya
Wang, Mincong
Ma, Xiulong
Li, Wen
Guo, Yuyan
Li, Yiming
author_sort Ren, Hongtao
collection PubMed
description Matrine exhibits anti-tumor effect on the proliferation and invasion of colorectal cancer (CRC) cells by reducing the activity of the p38 signaling pathway. However, these studies were limited because the underlying mechanism by which matrine inhibited CRC progression remained unclear. In this study, we provided for the first time that endoplasmic reticulum lipid raft associated protein 1 (Erlin1) is a novel target of matrine. Erlin1 was significantly upregulated in tumors and its knockdown suppressed the proliferation and migration of CRC cells, while its overexpression promoted CRC cell growth and migration. Furthermore, Erlin1 overexpression promoted inhibited apoptosis. Importantly, matrine treatment could reverse the oncogenic function of Erlin1 on CRC cell proliferation and migration. When Erlin1 was knocked down, matrine exhibited a more obvious anti-tumor effect in CRC cells. Partly due to this, matrine functions as an important anti-tumor drug and the results discovered here may clarify the mechanisms of matrine application for CRC treatment. CRC patients with low expression of Erlin1 might be more suitable for the treatment of matrine. This study could promote the application of matrine to be a promising therapeutic strategy for CRC patients.
format Online
Article
Text
id pubmed-9161898
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-91618982022-06-03 Matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression Ren, Hongtao Wang, Yali Guo, Ya Wang, Mincong Ma, Xiulong Li, Wen Guo, Yuyan Li, Yiming Bioengineered Research Paper Matrine exhibits anti-tumor effect on the proliferation and invasion of colorectal cancer (CRC) cells by reducing the activity of the p38 signaling pathway. However, these studies were limited because the underlying mechanism by which matrine inhibited CRC progression remained unclear. In this study, we provided for the first time that endoplasmic reticulum lipid raft associated protein 1 (Erlin1) is a novel target of matrine. Erlin1 was significantly upregulated in tumors and its knockdown suppressed the proliferation and migration of CRC cells, while its overexpression promoted CRC cell growth and migration. Furthermore, Erlin1 overexpression promoted inhibited apoptosis. Importantly, matrine treatment could reverse the oncogenic function of Erlin1 on CRC cell proliferation and migration. When Erlin1 was knocked down, matrine exhibited a more obvious anti-tumor effect in CRC cells. Partly due to this, matrine functions as an important anti-tumor drug and the results discovered here may clarify the mechanisms of matrine application for CRC treatment. CRC patients with low expression of Erlin1 might be more suitable for the treatment of matrine. This study could promote the application of matrine to be a promising therapeutic strategy for CRC patients. Taylor & Francis 2022-04-12 /pmc/articles/PMC9161898/ /pubmed/35412433 http://dx.doi.org/10.1080/21655979.2022.2060777 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Ren, Hongtao
Wang, Yali
Guo, Ya
Wang, Mincong
Ma, Xiulong
Li, Wen
Guo, Yuyan
Li, Yiming
Matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression
title Matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression
title_full Matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression
title_fullStr Matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression
title_full_unstemmed Matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression
title_short Matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression
title_sort matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161898/
https://www.ncbi.nlm.nih.gov/pubmed/35412433
http://dx.doi.org/10.1080/21655979.2022.2060777
work_keys_str_mv AT renhongtao matrineimpedescolorectalcancerproliferationandmigrationbydownregulatingendoplasmicreticulumlipidraftassociatedprotein1expression
AT wangyali matrineimpedescolorectalcancerproliferationandmigrationbydownregulatingendoplasmicreticulumlipidraftassociatedprotein1expression
AT guoya matrineimpedescolorectalcancerproliferationandmigrationbydownregulatingendoplasmicreticulumlipidraftassociatedprotein1expression
AT wangmincong matrineimpedescolorectalcancerproliferationandmigrationbydownregulatingendoplasmicreticulumlipidraftassociatedprotein1expression
AT maxiulong matrineimpedescolorectalcancerproliferationandmigrationbydownregulatingendoplasmicreticulumlipidraftassociatedprotein1expression
AT liwen matrineimpedescolorectalcancerproliferationandmigrationbydownregulatingendoplasmicreticulumlipidraftassociatedprotein1expression
AT guoyuyan matrineimpedescolorectalcancerproliferationandmigrationbydownregulatingendoplasmicreticulumlipidraftassociatedprotein1expression
AT liyiming matrineimpedescolorectalcancerproliferationandmigrationbydownregulatingendoplasmicreticulumlipidraftassociatedprotein1expression