Cargando…

Dexmedetomidine promotes cell proliferation and inhibits cell apoptosis by regulating LINC00982 and activating the phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT) signaling in hypoxia/reoxygenation-induced H9c2 cells

Previous studies showed dexmedetomidine (DEX) could alleviate myocardial ischemia/reperfusion injury (MIRI). Nevertheless, the mechanisms by which DEX alleviated MIRI remain to be determined. Our results demonstrated that DEX reversed hypoxia/reoxygenation (H/R)-induced decreased proliferation, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Tao, Li, Zhen, Xia, Shuyun, Xu, Zhixin, Chen, Xiaofang, Sun, Hu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161950/ https://www.ncbi.nlm.nih.gov/pubmed/35466860 http://dx.doi.org/10.1080/21655979.2022.2060900

Ejemplares similares

Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK)
por: Huang, Xueqin, et al.
Publicado: (2023)

Overexpression of long non-coding RNA LINC00982 suppresses cell proliferation and tumor growth of papillary thyroid carcinoma through PI3K-ATK signaling pathway
por: Xu, Debin, et al.
Publicado: (2019)

Berberine Induced Apoptosis of Human Osteosarcoma Cells by Inhibiting Phosphoinositide 3 Kinase/Protein Kinase B (PI3K/Akt) Signal Pathway Activation
por: CHEN, Zhi-Ze
Publicado: (2016)

A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?
por: McGonnell, Imelda M., et al.
Publicado: (2012)

Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer
por: Koundouros, Nikos, et al.
Publicado: (2018)

The Role of Phosphoinositide 3-Kinase-Akt Signaling in Virus Infection
por: Cooray, Samantha
Publicado: (2007)

Beyond PI3Ks: targeting phosphoinositide kinases in disease
por: Burke, John E., et al.
Publicado: (2022)

Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC)
por: Jung, Kyungsuk, et al.
Publicado: (2018)

Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway
por: Soo, Hsien-Chuen, et al.
Publicado: (2017)

Protein Kinase Activity of Phosphoinositide 3-Kinase Regulates Cytokine-Dependent Cell Survival
por: Thomas, Daniel, et al.
Publicado: (2013)

PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell deathPIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death
por: Chan, Chi Bun, et al.
Publicado: (2007)

Phosphoinositide-3 Kinase-Akt Pathway Controls Cellular Entry of Ebola Virus
por: Saeed, Mohammad F., et al.
Publicado: (2008)

Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase pathways
por: Dai, Zixun, et al.
Publicado: (2021)

Signaling via Class IA Phosphoinositide 3-Kinases (PI3K) in Human, Breast-Derived Cell Lines
por: Juvin, Veronique, et al.
Publicado: (2013)

Phosphoinositide 3–kinase γ participates in T cell receptor–induced T cell activation
por: Alcázar, Isabela, et al.
Publicado: (2007)

Phosphoinositide 3-Kinase signaling pathway: the key to cell proliferation and death
por: Peacock, Justin
Publicado: (2007)

Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells
por: Condliffe, Alison M, et al.
Publicado: (2000)

Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis
por: Tibolla, Gianpaolo, et al.
Publicado: (2013)

Identification of Novel Piperazinylquinoxaline Derivatives as Potent Phosphoinositide 3-Kinase (PI3K) Inhibitors
por: Wu, Peng, et al.
Publicado: (2012)

Phosphoinositide 3-Kinase (PI3K) Inhibitors and Breast Cancer: An Overview of Current Achievements
por: Bertucci, Alexandre, et al.
Publicado: (2023)

Phosphoinositide 3-Kinase Inhibitor-Induced Hyperglycemia
por: Shey, Susan, et al.
Publicado: (2021)

Dihydrotestosterone induces SREBP-1 expression and lipogenesis through the phosphoinositide 3-kinase/Akt pathway in HaCaT cells
por: Zhou, Bing-rong, et al.
Publicado: (2012)

Bmal1 suppresses cancer cell invasion by blocking the phosphoinositide 3-kinase-Akt-MMP-2 signaling pathway
por: JUNG, CHAN-HUN, et al.
Publicado: (2013)

Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT
por: Shravah, Jayant, et al.
Publicado: (2014)

Synergistic anticancer effects of everolimus (RAD001) and Rhein on gastric cancer cells via phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway
por: Gao, Feng, et al.
Publicado: (2022)

Regulation of glucose metabolism in T cells: new insight into the role of Phosphoinositide 3-kinases
por: Finlay, David K.
Publicado: (2012)

Phosphoinositide 3-Kinase-Dependent Signalling Pathways in Cutaneous Squamous Cell Carcinomas
por: Janus, Joanna M., et al.
Publicado: (2017)

MON-LB128 Phosphoinositide 3-Kinase (PI3K) Inhibitor Induced Hyperglycemia With Alpelisib
por: Barsukova, Yuliya, et al.
Publicado: (2020)

Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy
por: Ksionda, Olga, et al.
Publicado: (2018)

Phosphoinositide 3-Kinase (PI3K) Subunit p110δ Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse
por: Hu, Xiwen, et al.
Publicado: (2016)

Omipalisib Inhibits Esophageal Squamous Cell Carcinoma Growth Through Inactivation of Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) and ERK Signaling
por: Zhu, Dong-shan, et al.
Publicado: (2020)

TIPE-2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3-kinase/AKT signaling pathway
por: Wang, Lin, et al.
Publicado: (2018)

Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation
por: Inabe, Kazunori, et al.
Publicado: (2002)

Dexmedetomidine attenuates hypoxia/reoxygenation injury in primary neonatal rat cardiomyocytes
por: Peng, Ke, et al.
Publicado: (2017)

The Role of Phosphoinositide 3-Kinase Signaling in Intestinal Inflammation
por: Cahill, Catherine M., et al.
Publicado: (2012)

The role of phosphoinositide 3-kinase subunits in chronic thyroiditis
por: Wojciechowska-Durczynska, Katarzyna, et al.
Publicado: (2012)

Phosphoinositide 3-kinase: friend and foe in cardiovascular disease
por: Ghigo, Alessandra, et al.
Publicado: (2015)

The phosphoinositide 3-kinase pathway and therapy resistance in cancer
por: Brown, Kristin K., et al.
Publicado: (2015)

Multiple Functions of Phosphoinositide-3 Kinase Enhancer (PIKE)
por: Chan, Chi Bun, et al.
Publicado: (2010)

Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment
por: Gyori, David, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_7apautr926ohd021nc48nnvu6h