Cargando…

Pharmacokinetic Exposures Associated With Oral Administration of Sorafenib in Dogs With Spontaneous Tumors

Sorafenib is a multi-kinase small molecule inhibitor that targets serine/threonine and tyrosine kinases including the RAF kinase family, VEGFR-2, and PDGFR. The aim of this study was to evaluate the systemic pharmacokinetics of a previously defined tolerable oral dose of sorafenib in tumor-bearing d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cawley, Jacob R., Stewart, Samuel D., Mochel, Jonathan Paul, Veluvolu, Sridhar, Khanna, Chand, Fenger, Joelle M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Veterinary Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162170/ https://www.ncbi.nlm.nih.gov/pubmed/35664857 http://dx.doi.org/10.3389/fvets.2022.888483

Ejemplares similares

Tear Film Pharmacokinetics and Systemic Absorption Following Topical Administration of 1% Prednisolone Acetate Ophthalmic Suspension in Dogs
por: Sebbag, Lionel, et al.
Publicado: (2020)

Pharmacokinetics of Oral Prednisone at Various Doses in Dogs: Preliminary Findings Using a Naïve Pooled-Data Approach
por: Sebbag, Lionel, et al.
Publicado: (2020)

Pharmacokinetics of cannabidiol following single oral and oral transmucosal administration in dogs
por: della Rocca, Giorgia, et al.
Publicado: (2023)

Pharmacokinetics of Cannabidiol Following Intranasal, Intrarectal, and Oral Administration in Healthy Dogs
por: Polidoro, Dakir, et al.
Publicado: (2022)

Tolerability of oral sorafenib in pet dogs with a diagnosis of cancer
por: Foskett, Amanda, et al.
Publicado: (2017)

In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs
por: Musser, Margaret L., et al.
Publicado: (2019)

Pharmacokinetics and Tissue Levels of Pantoprazole in Neonatal Calves After Intravenous Administration
por: Olivarez, Jeff D., et al.
Publicado: (2020)

Pharmacokinetics of Intravenous, Intramuscular, Oral, and Transdermal Administration of Flunixin Meglumine in Pre-wean Piglets
por: Kittrell, Heather C., et al.
Publicado: (2020)

Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs
por: Pelligand, Ludovic, et al.
Publicado: (2020)

Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs
por: Wang, Jianzhong, et al.
Publicado: (2019)

Kinetics and minimal inhibitory concentrations of ceftiofur in tear film following extended-release parenteral administration (Excede(®)) in dogs
por: Bowden, Anna Catherine, et al.
Publicado: (2022)

Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report
por: Smith, Joe S., et al.
Publicado: (2021)

Pharmacokinetics of Pimobendan and Its Metabolite O-Desmethyl-Pimobendan Following Rectal Administration to Healthy Dogs
por: Her, Jiwoong, et al.
Publicado: (2020)

Tear Fluid Pharmacokinetics Following Oral Prednisone Administration in Dogs With and Without Conjunctivitis
por: Sebbag, Lionel, et al.
Publicado: (2019)

Pharmacokinetics of Single-Dose Oral Pregabalin Administration in Normal Cats
por: Esteban, Michaela A., et al.
Publicado: (2018)

Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury
por: Jeffery, Nick, et al.
Publicado: (2018)

Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration
por: Serpa, Priscila B. S., et al.
Publicado: (2018)

Exploring the benefits of in-diet versus repeated oral dosing of saracatinib (AZD0530) in chronic studies: insights into pharmacokinetics and animal welfare
por: Vasanthi, Suraj S., et al.
Publicado: (2023)

Pharmacokinetics and Biologic Activity of Apixaban in Healthy Dogs
por: Herrera, Noelle D., et al.
Publicado: (2021)

The Pharmacokinetics of Doxycycline in Channel Catfish (Ictalurus punctatus) Following Intravenous and Oral Administrations
por: Xu, Ning, et al.
Publicado: (2020)

Plasma Pharmacokinetics of Cannabidiol Following Oral Administration of Cannabidiol Oil to Dairy Calves
por: Meyer, Kelsey, et al.
Publicado: (2022)

Intravenous Topiramate: Pharmacokinetics in Dogs with Naturally Occurring Epilepsy
por: Vuu, Irene, et al.
Publicado: (2016)

Pharmacokinetics of mebendazole in plasma and cerebrospinal fluid following a single oral dose in healthy dogs
por: Yanke, Amy B., et al.
Publicado: (2023)

Pharmacokinetics of Tylvalosin in Broiler Turkeys (Meleagris Gallopavo) After Single Intravenous and Oral Administration
por: Elbadawy, Mohamed, et al.
Publicado: (2019)

Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs
por: Gamble, Lauri-Jo, et al.
Publicado: (2018)

Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge
por: Di Salvo, Alessandra, et al.
Publicado: (2023)

Pharmacokinetic and pharmacodynamic properties of pantoprazole in calves
por: Olivarez, Jeff D., et al.
Publicado: (2023)

Pharmacokinetics of menbutone after intravenous and intramuscular administration to sheep
por: Diez, Raquel, et al.
Publicado: (2022)

Kinetics of Fluorescein in Tear Film After Eye Drop Instillation in Beagle Dogs: Does Size Really Matter?
por: Sebbag, Lionel, et al.
Publicado: (2019)

Retrospective Evaluation of Clinical Bleeding in Dogs With Anticoagulant Rodenticide Toxicity—A Multi-Center Evaluation of 62 Cases (2010–2020)
por: Stroope, Sarah, et al.
Publicado: (2022)

In vitro Dissolution Testing and Pharmacokinetic Studies of Silymarin Solid Dispersion After Oral Administration to Healthy Pigs
por: Xu, Ying, et al.
Publicado: (2022)

An Assessment of the Stability of the Canine Oral Microbiota After Probiotic Administration in Healthy Dogs Over Time
por: Bell, Sara E., et al.
Publicado: (2020)

Comparative Pharmacokinetics of Meloxicam Between Healthy Post-partum vs. Mid-lactation Dairy Cattle
por: Warner, Rochelle, et al.
Publicado: (2020)

Phenylbutazone concentrations in synovial fluid following administration via intravenous regional limb perfusion in the forelimbs of six adult horses
por: O’Brien, Molly, et al.
Publicado: (2023)

Corrigendum: Comparative Pharmacokinetics of Meloxicam Between Healthy Post-partum vs. Mid-lactation Dairy Cattle
por: Warner, Rochelle, et al.
Publicado: (2021)

Pharmacokinetics and Tissue Distribution of Enrofloxacin Following Single Oral Administration in Yellow River Carp (Cyprinus carpio haematoperus)
por: Yang, Fan, et al.
Publicado: (2022)

Pharmacokinetics and Immunogenicity of Frunevetmab in Osteoarthritic Cats Following Intravenous and Subcutaneous Administration
por: Walters, Rodney R., et al.
Publicado: (2021)

Non-Linear Mixed-Effects Pharmacokinetic Modeling of the Novel COX-2 Selective Inhibitor Vitacoxib in Cats
por: Wang, Jianzhong, et al.
Publicado: (2020)

Pharmacokinetic and Safety Evaluation of Various Oral Doses of a Novel 1:20 THC:CBD Cannabis Herbal Extract in Dogs
por: Chicoine, Alan, et al.
Publicado: (2020)

Pharmacodynamics and Pharmacokinetics of Injectable Pimobendan and Its Metabolite, O-Desmethyl-Pimobendan, in Healthy Dogs
por: Pichayapaiboon, Poonavit, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sdc44v0qetask4abi8o8b2f9a0