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The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study
OBJECTIVES: The target of this work was to investigate vitamin K2 level link to glycaemic status in type 2 diabetes mellitus (T2DM) patients. METHODOLOGY: Sixty T2DM patients were divided into 30 uncontrolled T2DM (group I), 30 controlled T2DM (group II) patients and 30 non-diabetic subjects as the...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162250/ https://www.ncbi.nlm.nih.gov/pubmed/35662764 http://dx.doi.org/10.4103/ijem.ijem_470_21 |
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author | Helmy, Mona Yousry Elsaid, Nehal Hamdy Gwad, Marwa Mohammed Abdel |
author_facet | Helmy, Mona Yousry Elsaid, Nehal Hamdy Gwad, Marwa Mohammed Abdel |
author_sort | Helmy, Mona Yousry |
collection | PubMed |
description | OBJECTIVES: The target of this work was to investigate vitamin K2 level link to glycaemic status in type 2 diabetes mellitus (T2DM) patients. METHODOLOGY: Sixty T2DM patients were divided into 30 uncontrolled T2DM (group I), 30 controlled T2DM (group II) patients and 30 non-diabetic subjects as the control group. Vitamin K2 level, fasting insulin, homeostasis model assessment insulin resistance (HOMA-IR), fasting blood glucose (FBG), 2-h postprandial blood glucose (PPG), glycosylated haemoglobin (HbA1c) and fasting lipids were documented. Waist circumference (WC) was measured and body mass index (BMI) was calculated. RESULTS: A highly significant difference between groups was observed in vitamin K2 level (P < 0.001) being 1.61 ± 0.56 ng/ml, 2.04 ± 0.59 ng/ml and 2.96 ± 0.82 ng/ml for groups I, II and III, respectively. Among diabetics, a negative correlation was reported between serum vitamin K2 and FBG (r -0.428), 2-h PPBG (r -0.319), HbA1c (r -0.268), fasting insulin (r -0.49), HOMA-IR (r -0.5), total cholesterol (T-cholesterol) (r -0.335) and LDL-C (r -0.296) with P < 0.05. The receiver operating characteristic (ROC) curve emphasized the utility of the discriminated potentiality of serum vitamin K2 as a biomarker for uncontrolled hyperglycaemia in T2DM. The multivariate linear regression has shown that FBG is the only significant independent predictor of serum levels of vitamin K2. CONCLUSIONS: In T2DM patients, serum vitamin K2 level was significantly lower, especially with uncontrolled hyperglycaemia. This suggests that vitamin K2 level has an association with the glycaemic status in T2DM. |
format | Online Article Text |
id | pubmed-9162250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-91622502022-06-03 The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study Helmy, Mona Yousry Elsaid, Nehal Hamdy Gwad, Marwa Mohammed Abdel Indian J Endocrinol Metab Original Article OBJECTIVES: The target of this work was to investigate vitamin K2 level link to glycaemic status in type 2 diabetes mellitus (T2DM) patients. METHODOLOGY: Sixty T2DM patients were divided into 30 uncontrolled T2DM (group I), 30 controlled T2DM (group II) patients and 30 non-diabetic subjects as the control group. Vitamin K2 level, fasting insulin, homeostasis model assessment insulin resistance (HOMA-IR), fasting blood glucose (FBG), 2-h postprandial blood glucose (PPG), glycosylated haemoglobin (HbA1c) and fasting lipids were documented. Waist circumference (WC) was measured and body mass index (BMI) was calculated. RESULTS: A highly significant difference between groups was observed in vitamin K2 level (P < 0.001) being 1.61 ± 0.56 ng/ml, 2.04 ± 0.59 ng/ml and 2.96 ± 0.82 ng/ml for groups I, II and III, respectively. Among diabetics, a negative correlation was reported between serum vitamin K2 and FBG (r -0.428), 2-h PPBG (r -0.319), HbA1c (r -0.268), fasting insulin (r -0.49), HOMA-IR (r -0.5), total cholesterol (T-cholesterol) (r -0.335) and LDL-C (r -0.296) with P < 0.05. The receiver operating characteristic (ROC) curve emphasized the utility of the discriminated potentiality of serum vitamin K2 as a biomarker for uncontrolled hyperglycaemia in T2DM. The multivariate linear regression has shown that FBG is the only significant independent predictor of serum levels of vitamin K2. CONCLUSIONS: In T2DM patients, serum vitamin K2 level was significantly lower, especially with uncontrolled hyperglycaemia. This suggests that vitamin K2 level has an association with the glycaemic status in T2DM. Wolters Kluwer - Medknow 2022 2022-04-27 /pmc/articles/PMC9162250/ /pubmed/35662764 http://dx.doi.org/10.4103/ijem.ijem_470_21 Text en Copyright: © 2022 Indian Journal of Endocrinology and Metabolism https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Helmy, Mona Yousry Elsaid, Nehal Hamdy Gwad, Marwa Mohammed Abdel The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study |
title | The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study |
title_full | The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study |
title_fullStr | The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study |
title_full_unstemmed | The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study |
title_short | The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study |
title_sort | association of vitamin k2 level with the glycaemic status in type 2 diabetic patients: a case-control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162250/ https://www.ncbi.nlm.nih.gov/pubmed/35662764 http://dx.doi.org/10.4103/ijem.ijem_470_21 |
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