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The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study

OBJECTIVES: The target of this work was to investigate vitamin K2 level link to glycaemic status in type 2 diabetes mellitus (T2DM) patients. METHODOLOGY: Sixty T2DM patients were divided into 30 uncontrolled T2DM (group I), 30 controlled T2DM (group II) patients and 30 non-diabetic subjects as the...

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Autores principales: Helmy, Mona Yousry, Elsaid, Nehal Hamdy, Gwad, Marwa Mohammed Abdel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162250/
https://www.ncbi.nlm.nih.gov/pubmed/35662764
http://dx.doi.org/10.4103/ijem.ijem_470_21
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author Helmy, Mona Yousry
Elsaid, Nehal Hamdy
Gwad, Marwa Mohammed Abdel
author_facet Helmy, Mona Yousry
Elsaid, Nehal Hamdy
Gwad, Marwa Mohammed Abdel
author_sort Helmy, Mona Yousry
collection PubMed
description OBJECTIVES: The target of this work was to investigate vitamin K2 level link to glycaemic status in type 2 diabetes mellitus (T2DM) patients. METHODOLOGY: Sixty T2DM patients were divided into 30 uncontrolled T2DM (group I), 30 controlled T2DM (group II) patients and 30 non-diabetic subjects as the control group. Vitamin K2 level, fasting insulin, homeostasis model assessment insulin resistance (HOMA-IR), fasting blood glucose (FBG), 2-h postprandial blood glucose (PPG), glycosylated haemoglobin (HbA1c) and fasting lipids were documented. Waist circumference (WC) was measured and body mass index (BMI) was calculated. RESULTS: A highly significant difference between groups was observed in vitamin K2 level (P < 0.001) being 1.61 ± 0.56 ng/ml, 2.04 ± 0.59 ng/ml and 2.96 ± 0.82 ng/ml for groups I, II and III, respectively. Among diabetics, a negative correlation was reported between serum vitamin K2 and FBG (r -0.428), 2-h PPBG (r -0.319), HbA1c (r -0.268), fasting insulin (r -0.49), HOMA-IR (r -0.5), total cholesterol (T-cholesterol) (r -0.335) and LDL-C (r -0.296) with P < 0.05. The receiver operating characteristic (ROC) curve emphasized the utility of the discriminated potentiality of serum vitamin K2 as a biomarker for uncontrolled hyperglycaemia in T2DM. The multivariate linear regression has shown that FBG is the only significant independent predictor of serum levels of vitamin K2. CONCLUSIONS: In T2DM patients, serum vitamin K2 level was significantly lower, especially with uncontrolled hyperglycaemia. This suggests that vitamin K2 level has an association with the glycaemic status in T2DM.
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spelling pubmed-91622502022-06-03 The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study Helmy, Mona Yousry Elsaid, Nehal Hamdy Gwad, Marwa Mohammed Abdel Indian J Endocrinol Metab Original Article OBJECTIVES: The target of this work was to investigate vitamin K2 level link to glycaemic status in type 2 diabetes mellitus (T2DM) patients. METHODOLOGY: Sixty T2DM patients were divided into 30 uncontrolled T2DM (group I), 30 controlled T2DM (group II) patients and 30 non-diabetic subjects as the control group. Vitamin K2 level, fasting insulin, homeostasis model assessment insulin resistance (HOMA-IR), fasting blood glucose (FBG), 2-h postprandial blood glucose (PPG), glycosylated haemoglobin (HbA1c) and fasting lipids were documented. Waist circumference (WC) was measured and body mass index (BMI) was calculated. RESULTS: A highly significant difference between groups was observed in vitamin K2 level (P < 0.001) being 1.61 ± 0.56 ng/ml, 2.04 ± 0.59 ng/ml and 2.96 ± 0.82 ng/ml for groups I, II and III, respectively. Among diabetics, a negative correlation was reported between serum vitamin K2 and FBG (r -0.428), 2-h PPBG (r -0.319), HbA1c (r -0.268), fasting insulin (r -0.49), HOMA-IR (r -0.5), total cholesterol (T-cholesterol) (r -0.335) and LDL-C (r -0.296) with P < 0.05. The receiver operating characteristic (ROC) curve emphasized the utility of the discriminated potentiality of serum vitamin K2 as a biomarker for uncontrolled hyperglycaemia in T2DM. The multivariate linear regression has shown that FBG is the only significant independent predictor of serum levels of vitamin K2. CONCLUSIONS: In T2DM patients, serum vitamin K2 level was significantly lower, especially with uncontrolled hyperglycaemia. This suggests that vitamin K2 level has an association with the glycaemic status in T2DM. Wolters Kluwer - Medknow 2022 2022-04-27 /pmc/articles/PMC9162250/ /pubmed/35662764 http://dx.doi.org/10.4103/ijem.ijem_470_21 Text en Copyright: © 2022 Indian Journal of Endocrinology and Metabolism https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Helmy, Mona Yousry
Elsaid, Nehal Hamdy
Gwad, Marwa Mohammed Abdel
The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study
title The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study
title_full The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study
title_fullStr The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study
title_full_unstemmed The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study
title_short The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study
title_sort association of vitamin k2 level with the glycaemic status in type 2 diabetic patients: a case-control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162250/
https://www.ncbi.nlm.nih.gov/pubmed/35662764
http://dx.doi.org/10.4103/ijem.ijem_470_21
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