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Risk of liver fibrosis in patients with prediabetes and diabetes mellitus

The aim of this study was to assess the risk of liver fibrosis in those with no glucose intolerance, prediabetes, or diabetes. A cross-sectional study was conducted based on a cohort from a health examination program which included a magnetic resonance elastography (MRE). Participants were classifie...

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Autores principales: Park, Jongsin, Kwon, Heon-Ju, Sohn, Won, Cho, Ju-Yeon, Park, Soo Jin, Chang, Yoosoo, Ryu, Seungho, Kim, Byung Ik, Cho, Yong Kyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162349/
https://www.ncbi.nlm.nih.gov/pubmed/35653399
http://dx.doi.org/10.1371/journal.pone.0269070
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author Park, Jongsin
Kwon, Heon-Ju
Sohn, Won
Cho, Ju-Yeon
Park, Soo Jin
Chang, Yoosoo
Ryu, Seungho
Kim, Byung Ik
Cho, Yong Kyun
author_facet Park, Jongsin
Kwon, Heon-Ju
Sohn, Won
Cho, Ju-Yeon
Park, Soo Jin
Chang, Yoosoo
Ryu, Seungho
Kim, Byung Ik
Cho, Yong Kyun
author_sort Park, Jongsin
collection PubMed
description The aim of this study was to assess the risk of liver fibrosis in those with no glucose intolerance, prediabetes, or diabetes. A cross-sectional study was conducted based on a cohort from a health examination program which included a magnetic resonance elastography (MRE). Participants were classified into three groups according to glucose tolerance: no glucose intolerance, prediabetes, and diabetes mellitus. Liver fibrosis was evaluated by liver stiffness measurement (LSM) value using two-dimensional real-time MRE. The risk of significant liver fibrosis was compared among three groups. A total of 2,090 subjects were included: no glucose intolerance (n = 889); prediabetes (n = 985); and diabetes (n = 216). Mean values of LSM in those with no glucose intolerance, prediabetes, and diabetes were 2.37 ± 0.43 kPa, 2.41 ± 0.34 kPa, and 2.65 ± 0.70 kPa, respectively (p<0.001). Proportions of significant fibrosis (LSM ≥2.97 kPa) in no glucose intolerance, prediabetes, and diabetes groups were 3.1%, 4.4%, and 16.7%, respectively (p<0.001). Compared with those with no glucose intolerance, those with diabetes had higher risk of significant fibrosis (adjusted odds ratio [aOR]: 3.02, 95% confidence interval [CI]: 1.57–5.81, p<0.001). However, there was no difference between prediabetes and no glucose intolerance (aOR: 1.05, 95% CI: 0.59–1.86, p = 0.876). A subgroup analysis also showed that prediabetes, unlike diabetes, was not associated with significant fibrosis in subjects with or without liver disease. Diabetes, but not prediabetes, is a risk factor for significant liver fibrosis. This finding is consistent regarldess of the pressence of liver disease.
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spelling pubmed-91623492022-06-03 Risk of liver fibrosis in patients with prediabetes and diabetes mellitus Park, Jongsin Kwon, Heon-Ju Sohn, Won Cho, Ju-Yeon Park, Soo Jin Chang, Yoosoo Ryu, Seungho Kim, Byung Ik Cho, Yong Kyun PLoS One Research Article The aim of this study was to assess the risk of liver fibrosis in those with no glucose intolerance, prediabetes, or diabetes. A cross-sectional study was conducted based on a cohort from a health examination program which included a magnetic resonance elastography (MRE). Participants were classified into three groups according to glucose tolerance: no glucose intolerance, prediabetes, and diabetes mellitus. Liver fibrosis was evaluated by liver stiffness measurement (LSM) value using two-dimensional real-time MRE. The risk of significant liver fibrosis was compared among three groups. A total of 2,090 subjects were included: no glucose intolerance (n = 889); prediabetes (n = 985); and diabetes (n = 216). Mean values of LSM in those with no glucose intolerance, prediabetes, and diabetes were 2.37 ± 0.43 kPa, 2.41 ± 0.34 kPa, and 2.65 ± 0.70 kPa, respectively (p<0.001). Proportions of significant fibrosis (LSM ≥2.97 kPa) in no glucose intolerance, prediabetes, and diabetes groups were 3.1%, 4.4%, and 16.7%, respectively (p<0.001). Compared with those with no glucose intolerance, those with diabetes had higher risk of significant fibrosis (adjusted odds ratio [aOR]: 3.02, 95% confidence interval [CI]: 1.57–5.81, p<0.001). However, there was no difference between prediabetes and no glucose intolerance (aOR: 1.05, 95% CI: 0.59–1.86, p = 0.876). A subgroup analysis also showed that prediabetes, unlike diabetes, was not associated with significant fibrosis in subjects with or without liver disease. Diabetes, but not prediabetes, is a risk factor for significant liver fibrosis. This finding is consistent regarldess of the pressence of liver disease. Public Library of Science 2022-06-02 /pmc/articles/PMC9162349/ /pubmed/35653399 http://dx.doi.org/10.1371/journal.pone.0269070 Text en © 2022 Park et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Park, Jongsin
Kwon, Heon-Ju
Sohn, Won
Cho, Ju-Yeon
Park, Soo Jin
Chang, Yoosoo
Ryu, Seungho
Kim, Byung Ik
Cho, Yong Kyun
Risk of liver fibrosis in patients with prediabetes and diabetes mellitus
title Risk of liver fibrosis in patients with prediabetes and diabetes mellitus
title_full Risk of liver fibrosis in patients with prediabetes and diabetes mellitus
title_fullStr Risk of liver fibrosis in patients with prediabetes and diabetes mellitus
title_full_unstemmed Risk of liver fibrosis in patients with prediabetes and diabetes mellitus
title_short Risk of liver fibrosis in patients with prediabetes and diabetes mellitus
title_sort risk of liver fibrosis in patients with prediabetes and diabetes mellitus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162349/
https://www.ncbi.nlm.nih.gov/pubmed/35653399
http://dx.doi.org/10.1371/journal.pone.0269070
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