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Risk of liver fibrosis in patients with prediabetes and diabetes mellitus
The aim of this study was to assess the risk of liver fibrosis in those with no glucose intolerance, prediabetes, or diabetes. A cross-sectional study was conducted based on a cohort from a health examination program which included a magnetic resonance elastography (MRE). Participants were classifie...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162349/ https://www.ncbi.nlm.nih.gov/pubmed/35653399 http://dx.doi.org/10.1371/journal.pone.0269070 |
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author | Park, Jongsin Kwon, Heon-Ju Sohn, Won Cho, Ju-Yeon Park, Soo Jin Chang, Yoosoo Ryu, Seungho Kim, Byung Ik Cho, Yong Kyun |
author_facet | Park, Jongsin Kwon, Heon-Ju Sohn, Won Cho, Ju-Yeon Park, Soo Jin Chang, Yoosoo Ryu, Seungho Kim, Byung Ik Cho, Yong Kyun |
author_sort | Park, Jongsin |
collection | PubMed |
description | The aim of this study was to assess the risk of liver fibrosis in those with no glucose intolerance, prediabetes, or diabetes. A cross-sectional study was conducted based on a cohort from a health examination program which included a magnetic resonance elastography (MRE). Participants were classified into three groups according to glucose tolerance: no glucose intolerance, prediabetes, and diabetes mellitus. Liver fibrosis was evaluated by liver stiffness measurement (LSM) value using two-dimensional real-time MRE. The risk of significant liver fibrosis was compared among three groups. A total of 2,090 subjects were included: no glucose intolerance (n = 889); prediabetes (n = 985); and diabetes (n = 216). Mean values of LSM in those with no glucose intolerance, prediabetes, and diabetes were 2.37 ± 0.43 kPa, 2.41 ± 0.34 kPa, and 2.65 ± 0.70 kPa, respectively (p<0.001). Proportions of significant fibrosis (LSM ≥2.97 kPa) in no glucose intolerance, prediabetes, and diabetes groups were 3.1%, 4.4%, and 16.7%, respectively (p<0.001). Compared with those with no glucose intolerance, those with diabetes had higher risk of significant fibrosis (adjusted odds ratio [aOR]: 3.02, 95% confidence interval [CI]: 1.57–5.81, p<0.001). However, there was no difference between prediabetes and no glucose intolerance (aOR: 1.05, 95% CI: 0.59–1.86, p = 0.876). A subgroup analysis also showed that prediabetes, unlike diabetes, was not associated with significant fibrosis in subjects with or without liver disease. Diabetes, but not prediabetes, is a risk factor for significant liver fibrosis. This finding is consistent regarldess of the pressence of liver disease. |
format | Online Article Text |
id | pubmed-9162349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-91623492022-06-03 Risk of liver fibrosis in patients with prediabetes and diabetes mellitus Park, Jongsin Kwon, Heon-Ju Sohn, Won Cho, Ju-Yeon Park, Soo Jin Chang, Yoosoo Ryu, Seungho Kim, Byung Ik Cho, Yong Kyun PLoS One Research Article The aim of this study was to assess the risk of liver fibrosis in those with no glucose intolerance, prediabetes, or diabetes. A cross-sectional study was conducted based on a cohort from a health examination program which included a magnetic resonance elastography (MRE). Participants were classified into three groups according to glucose tolerance: no glucose intolerance, prediabetes, and diabetes mellitus. Liver fibrosis was evaluated by liver stiffness measurement (LSM) value using two-dimensional real-time MRE. The risk of significant liver fibrosis was compared among three groups. A total of 2,090 subjects were included: no glucose intolerance (n = 889); prediabetes (n = 985); and diabetes (n = 216). Mean values of LSM in those with no glucose intolerance, prediabetes, and diabetes were 2.37 ± 0.43 kPa, 2.41 ± 0.34 kPa, and 2.65 ± 0.70 kPa, respectively (p<0.001). Proportions of significant fibrosis (LSM ≥2.97 kPa) in no glucose intolerance, prediabetes, and diabetes groups were 3.1%, 4.4%, and 16.7%, respectively (p<0.001). Compared with those with no glucose intolerance, those with diabetes had higher risk of significant fibrosis (adjusted odds ratio [aOR]: 3.02, 95% confidence interval [CI]: 1.57–5.81, p<0.001). However, there was no difference between prediabetes and no glucose intolerance (aOR: 1.05, 95% CI: 0.59–1.86, p = 0.876). A subgroup analysis also showed that prediabetes, unlike diabetes, was not associated with significant fibrosis in subjects with or without liver disease. Diabetes, but not prediabetes, is a risk factor for significant liver fibrosis. This finding is consistent regarldess of the pressence of liver disease. Public Library of Science 2022-06-02 /pmc/articles/PMC9162349/ /pubmed/35653399 http://dx.doi.org/10.1371/journal.pone.0269070 Text en © 2022 Park et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Park, Jongsin Kwon, Heon-Ju Sohn, Won Cho, Ju-Yeon Park, Soo Jin Chang, Yoosoo Ryu, Seungho Kim, Byung Ik Cho, Yong Kyun Risk of liver fibrosis in patients with prediabetes and diabetes mellitus |
title | Risk of liver fibrosis in patients with prediabetes and diabetes mellitus |
title_full | Risk of liver fibrosis in patients with prediabetes and diabetes mellitus |
title_fullStr | Risk of liver fibrosis in patients with prediabetes and diabetes mellitus |
title_full_unstemmed | Risk of liver fibrosis in patients with prediabetes and diabetes mellitus |
title_short | Risk of liver fibrosis in patients with prediabetes and diabetes mellitus |
title_sort | risk of liver fibrosis in patients with prediabetes and diabetes mellitus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162349/ https://www.ncbi.nlm.nih.gov/pubmed/35653399 http://dx.doi.org/10.1371/journal.pone.0269070 |
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