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To be or not be (in the LAD): emerging roles of lamin proteins in transcriptional regulation
Lamins are components of the nuclear lamina, a protein meshwork that underlies the nuclear membrane. Lamins interact with chromatin in transcriptionally silent regions defined as lamina-associated-domains (LADs). However, recent studies have shown that lamins regulate active transcription inside LAD...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Portland Press Ltd.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162450/ https://www.ncbi.nlm.nih.gov/pubmed/35437578 http://dx.doi.org/10.1042/BST20210858 |
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author | Nazer, Ezequiel |
author_facet | Nazer, Ezequiel |
author_sort | Nazer, Ezequiel |
collection | PubMed |
description | Lamins are components of the nuclear lamina, a protein meshwork that underlies the nuclear membrane. Lamins interact with chromatin in transcriptionally silent regions defined as lamina-associated-domains (LADs). However, recent studies have shown that lamins regulate active transcription inside LADs. In addition, ChIP-seq analysis has shown that lamins interact with lamin-dependent promoters and enhancers located in the interior of the nucleus. Moreover, functional studies suggest that lamins regulate transcription at associated-promoters and long-range chromatin interactions of key developmental gene programs. This review will discuss emerging, non-canonical functions of lamins in controlling non-silent genes located both inside and outside of LADs, focusing on transcriptional regulation and chromatin organization in Drosophila and mammals as metazoan model organisms. |
format | Online Article Text |
id | pubmed-9162450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91624502022-06-07 To be or not be (in the LAD): emerging roles of lamin proteins in transcriptional regulation Nazer, Ezequiel Biochem Soc Trans Review Articles Lamins are components of the nuclear lamina, a protein meshwork that underlies the nuclear membrane. Lamins interact with chromatin in transcriptionally silent regions defined as lamina-associated-domains (LADs). However, recent studies have shown that lamins regulate active transcription inside LADs. In addition, ChIP-seq analysis has shown that lamins interact with lamin-dependent promoters and enhancers located in the interior of the nucleus. Moreover, functional studies suggest that lamins regulate transcription at associated-promoters and long-range chromatin interactions of key developmental gene programs. This review will discuss emerging, non-canonical functions of lamins in controlling non-silent genes located both inside and outside of LADs, focusing on transcriptional regulation and chromatin organization in Drosophila and mammals as metazoan model organisms. Portland Press Ltd. 2022-04-29 2022-04-19 /pmc/articles/PMC9162450/ /pubmed/35437578 http://dx.doi.org/10.1042/BST20210858 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Articles Nazer, Ezequiel To be or not be (in the LAD): emerging roles of lamin proteins in transcriptional regulation |
title | To be or not be (in the LAD): emerging roles of lamin proteins in transcriptional regulation |
title_full | To be or not be (in the LAD): emerging roles of lamin proteins in transcriptional regulation |
title_fullStr | To be or not be (in the LAD): emerging roles of lamin proteins in transcriptional regulation |
title_full_unstemmed | To be or not be (in the LAD): emerging roles of lamin proteins in transcriptional regulation |
title_short | To be or not be (in the LAD): emerging roles of lamin proteins in transcriptional regulation |
title_sort | to be or not be (in the lad): emerging roles of lamin proteins in transcriptional regulation |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162450/ https://www.ncbi.nlm.nih.gov/pubmed/35437578 http://dx.doi.org/10.1042/BST20210858 |
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