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Organ-on-a-chip: current gaps and future directions

As an emerging hot topic of the last decade, Organ on Chip (OoC) is a new technology that is attracting interest from both basic and translational scientists. The Biochemical Society, with its mission of supporting the advancement of science, with addressing grand challenges that have societal impac...

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Autores principales: Candarlioglu, Pelin L., Dal Negro, Gianni, Hughes, David, Balkwill, Frances, Harris, Kate, Screen, Hazel, Morgan, Hywel, David, Rhiannon, Beken, Sonja, Guenat, Olivier, Rowan, Wendy, Amour, Augustin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162452/
https://www.ncbi.nlm.nih.gov/pubmed/35437569
http://dx.doi.org/10.1042/BST20200661
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author Candarlioglu, Pelin L.
Dal Negro, Gianni
Hughes, David
Balkwill, Frances
Harris, Kate
Screen, Hazel
Morgan, Hywel
David, Rhiannon
Beken, Sonja
Guenat, Olivier
Rowan, Wendy
Amour, Augustin
author_facet Candarlioglu, Pelin L.
Dal Negro, Gianni
Hughes, David
Balkwill, Frances
Harris, Kate
Screen, Hazel
Morgan, Hywel
David, Rhiannon
Beken, Sonja
Guenat, Olivier
Rowan, Wendy
Amour, Augustin
author_sort Candarlioglu, Pelin L.
collection PubMed
description As an emerging hot topic of the last decade, Organ on Chip (OoC) is a new technology that is attracting interest from both basic and translational scientists. The Biochemical Society, with its mission of supporting the advancement of science, with addressing grand challenges that have societal impact, has included OoC into their agenda to review the current state of the art, bottlenecks and future directions. This conference brought together representatives of the main stakeholders in the OoC field including academics, end-users, regulators and technology developers to discuss and identify requirements for this new technology to deliver on par with the expectations and the key challenges and gaps that still need to be addressed to achieve robust human-relevant tools, able to positively impact decision making in the pharmaceutical industry and reduce overreliance on poorly predictive animal models.
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spelling pubmed-91624522022-06-07 Organ-on-a-chip: current gaps and future directions Candarlioglu, Pelin L. Dal Negro, Gianni Hughes, David Balkwill, Frances Harris, Kate Screen, Hazel Morgan, Hywel David, Rhiannon Beken, Sonja Guenat, Olivier Rowan, Wendy Amour, Augustin Biochem Soc Trans Review Articles As an emerging hot topic of the last decade, Organ on Chip (OoC) is a new technology that is attracting interest from both basic and translational scientists. The Biochemical Society, with its mission of supporting the advancement of science, with addressing grand challenges that have societal impact, has included OoC into their agenda to review the current state of the art, bottlenecks and future directions. This conference brought together representatives of the main stakeholders in the OoC field including academics, end-users, regulators and technology developers to discuss and identify requirements for this new technology to deliver on par with the expectations and the key challenges and gaps that still need to be addressed to achieve robust human-relevant tools, able to positively impact decision making in the pharmaceutical industry and reduce overreliance on poorly predictive animal models. Portland Press Ltd. 2022-04-29 2022-04-19 /pmc/articles/PMC9162452/ /pubmed/35437569 http://dx.doi.org/10.1042/BST20200661 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Candarlioglu, Pelin L.
Dal Negro, Gianni
Hughes, David
Balkwill, Frances
Harris, Kate
Screen, Hazel
Morgan, Hywel
David, Rhiannon
Beken, Sonja
Guenat, Olivier
Rowan, Wendy
Amour, Augustin
Organ-on-a-chip: current gaps and future directions
title Organ-on-a-chip: current gaps and future directions
title_full Organ-on-a-chip: current gaps and future directions
title_fullStr Organ-on-a-chip: current gaps and future directions
title_full_unstemmed Organ-on-a-chip: current gaps and future directions
title_short Organ-on-a-chip: current gaps and future directions
title_sort organ-on-a-chip: current gaps and future directions
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162452/
https://www.ncbi.nlm.nih.gov/pubmed/35437569
http://dx.doi.org/10.1042/BST20200661
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