MicroRNAs in neural crest development and neurocristopathies

The neural crest (NC) is a vertebrate-specific migratory population of multipotent stem cells that originate during late gastrulation in the region between the neural and non-neural ectoderm. This population of cells give rise to a range of derivatives, such as melanocytes, neurons, chondrocytes, ch...

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Autores principales: Antonaci, Marco, Wheeler, Grant N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162459/
https://www.ncbi.nlm.nih.gov/pubmed/35383827
http://dx.doi.org/10.1042/BST20210828
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author Antonaci, Marco
Wheeler, Grant N.
author_facet Antonaci, Marco
Wheeler, Grant N.
author_sort Antonaci, Marco
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description The neural crest (NC) is a vertebrate-specific migratory population of multipotent stem cells that originate during late gastrulation in the region between the neural and non-neural ectoderm. This population of cells give rise to a range of derivatives, such as melanocytes, neurons, chondrocytes, chromaffin cells, and osteoblasts. Because of this, failure of NC development can cause a variety of pathologies, often syndromic, that are globally called neurocristopathies. Many genes are known to be involved in NC development, but not all of them have been identified. In recent years, attention has moved from protein-coding genes to non-coding genes, such as microRNAs (miRNA). There is increasing evidence that these non-coding RNAs are playing roles during embryogenesis by regulating the expression of protein-coding genes. In this review, we give an introduction to miRNAs in general and then focus on some miRNAs that may be involved in NC development and neurocristopathies. This new direction of research will give geneticists, clinicians, and molecular biologists more tools to help patients affected by neurocristopathies, as well as broadening our understanding of NC biology.
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spelling pubmed-91624592022-06-07 MicroRNAs in neural crest development and neurocristopathies Antonaci, Marco Wheeler, Grant N. Biochem Soc Trans Review Articles The neural crest (NC) is a vertebrate-specific migratory population of multipotent stem cells that originate during late gastrulation in the region between the neural and non-neural ectoderm. This population of cells give rise to a range of derivatives, such as melanocytes, neurons, chondrocytes, chromaffin cells, and osteoblasts. Because of this, failure of NC development can cause a variety of pathologies, often syndromic, that are globally called neurocristopathies. Many genes are known to be involved in NC development, but not all of them have been identified. In recent years, attention has moved from protein-coding genes to non-coding genes, such as microRNAs (miRNA). There is increasing evidence that these non-coding RNAs are playing roles during embryogenesis by regulating the expression of protein-coding genes. In this review, we give an introduction to miRNAs in general and then focus on some miRNAs that may be involved in NC development and neurocristopathies. This new direction of research will give geneticists, clinicians, and molecular biologists more tools to help patients affected by neurocristopathies, as well as broadening our understanding of NC biology. Portland Press Ltd. 2022-04-29 2022-04-06 /pmc/articles/PMC9162459/ /pubmed/35383827 http://dx.doi.org/10.1042/BST20210828 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for this article was enabled by the participation of University of East Anglia in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC.
spellingShingle Review Articles
Antonaci, Marco
Wheeler, Grant N.
MicroRNAs in neural crest development and neurocristopathies
title MicroRNAs in neural crest development and neurocristopathies
title_full MicroRNAs in neural crest development and neurocristopathies
title_fullStr MicroRNAs in neural crest development and neurocristopathies
title_full_unstemmed MicroRNAs in neural crest development and neurocristopathies
title_short MicroRNAs in neural crest development and neurocristopathies
title_sort micrornas in neural crest development and neurocristopathies
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162459/
https://www.ncbi.nlm.nih.gov/pubmed/35383827
http://dx.doi.org/10.1042/BST20210828
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