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dbEssLnc: A manually curated database of human and mouse essential lncRNA genes

Long non-coding RNAs (lncRNAs) play important roles in many biological processes. Knocking out or knocking down some lncRNAs will lead to lethality or infertility. These lncRNAs are called essential lncRNAs. Knowledges of essential lncRNAs are important in establishing minimal genomes of living cell...

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Detalles Bibliográficos
Autores principales: Zhang, Ying-Ying, Zhang, Wen-Ya, Xin, Xiao-Hong, Du, Pu-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162909/
https://www.ncbi.nlm.nih.gov/pubmed/35685362
http://dx.doi.org/10.1016/j.csbj.2022.05.043
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author Zhang, Ying-Ying
Zhang, Wen-Ya
Xin, Xiao-Hong
Du, Pu-Feng
author_facet Zhang, Ying-Ying
Zhang, Wen-Ya
Xin, Xiao-Hong
Du, Pu-Feng
author_sort Zhang, Ying-Ying
collection PubMed
description Long non-coding RNAs (lncRNAs) play important roles in many biological processes. Knocking out or knocking down some lncRNAs will lead to lethality or infertility. These lncRNAs are called essential lncRNAs. Knowledges of essential lncRNAs are important in establishing minimal genomes of living cells, developing drug therapies and early diagnostic approaches for complex diseases. However, existing databases focus on collecting essential coding genes. Essential non-coding gene records are rare in existing databases. A comprehensive collection of essential non-coding genes, particularly essential lncRNA genes, is demanded. We manually curated 207 essential lncRNAs from literatures for establishing a database on essential lncRNAs, which is named as dbEssLnc (Database of essential lncRNAs). The dbEssLnc database has a web-based user-friendly interface for the users to browse, to search, to visualize and to blast search records in the database. The dbEssLnc database is freely accessible at https://esslnc.pufengdu.org. All data and source codes for mirroring the dbEssLnc database have been deposited in GitHub (https://github.com/yyZhang14/dbEssLnc).
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spelling pubmed-91629092022-06-08 dbEssLnc: A manually curated database of human and mouse essential lncRNA genes Zhang, Ying-Ying Zhang, Wen-Ya Xin, Xiao-Hong Du, Pu-Feng Comput Struct Biotechnol J Data Article Long non-coding RNAs (lncRNAs) play important roles in many biological processes. Knocking out or knocking down some lncRNAs will lead to lethality or infertility. These lncRNAs are called essential lncRNAs. Knowledges of essential lncRNAs are important in establishing minimal genomes of living cells, developing drug therapies and early diagnostic approaches for complex diseases. However, existing databases focus on collecting essential coding genes. Essential non-coding gene records are rare in existing databases. A comprehensive collection of essential non-coding genes, particularly essential lncRNA genes, is demanded. We manually curated 207 essential lncRNAs from literatures for establishing a database on essential lncRNAs, which is named as dbEssLnc (Database of essential lncRNAs). The dbEssLnc database has a web-based user-friendly interface for the users to browse, to search, to visualize and to blast search records in the database. The dbEssLnc database is freely accessible at https://esslnc.pufengdu.org. All data and source codes for mirroring the dbEssLnc database have been deposited in GitHub (https://github.com/yyZhang14/dbEssLnc). Research Network of Computational and Structural Biotechnology 2022-05-23 /pmc/articles/PMC9162909/ /pubmed/35685362 http://dx.doi.org/10.1016/j.csbj.2022.05.043 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Data Article
Zhang, Ying-Ying
Zhang, Wen-Ya
Xin, Xiao-Hong
Du, Pu-Feng
dbEssLnc: A manually curated database of human and mouse essential lncRNA genes
title dbEssLnc: A manually curated database of human and mouse essential lncRNA genes
title_full dbEssLnc: A manually curated database of human and mouse essential lncRNA genes
title_fullStr dbEssLnc: A manually curated database of human and mouse essential lncRNA genes
title_full_unstemmed dbEssLnc: A manually curated database of human and mouse essential lncRNA genes
title_short dbEssLnc: A manually curated database of human and mouse essential lncRNA genes
title_sort dbesslnc: a manually curated database of human and mouse essential lncrna genes
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162909/
https://www.ncbi.nlm.nih.gov/pubmed/35685362
http://dx.doi.org/10.1016/j.csbj.2022.05.043
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