Semi-automated validation and quantification of CTLA-4 in 90 different tumor entities using multiple antibodies and artificial intelligence

CTLA-4 is an inhibitory immune checkpoint receptor and a negative regulator of anti-tumor T-cell function. This study is aimed for a comparative analysis of CTLA-4(+) cells between different tumor entities. To quantify CTLA-4(+) cells, 4582 tumor samples from 90 different tumor entities as well as 6...

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Detalles Bibliográficos
Autores principales: Dum, David, Henke, Tjark L. C., Mandelkow, Tim, Yang, Cheng, Bady, Elena, Raedler, Jonas B., Simon, Ronald, Sauter, Guido, Lennartz, Maximilian, Büscheck, Franziska, Luebke, Andreas M., Menz, Anne, Hinsch, Andrea, Höflmayer, Doris, Weidemann, Sören, Fraune, Christoph, Möller, Katharina, Lebok, Patrick, Uhlig, Ria, Bernreuther, Christian, Jacobsen, Frank, Clauditz, Till S., Wilczak, Waldemar, Minner, Sarah, Burandt, Eike, Steurer, Stefan, Blessin, Niclas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162915/
https://www.ncbi.nlm.nih.gov/pubmed/35091676
http://dx.doi.org/10.1038/s41374-022-00728-4

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