Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive pediatric cancer. Amongst the wide array of driver mutations, 10% of T-ALL patients display gain-of-function mutations in the IL-7 receptor α chain (IL-7Rα, encoded by IL7R), which occur in different molecular subtypes of this disease. How...

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Detalles Bibliográficos
Autores principales: Oliveira, Mariana L., Veloso, Alexandra, Garcia, Elaine G., Iyer, Sowmya, Pereira, Clara, Barreto, Vasco M., Langenau, David M., Barata, João T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162918/
https://www.ncbi.nlm.nih.gov/pubmed/35581375
http://dx.doi.org/10.1038/s41375-022-01590-5

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