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Hierarchical length and sequence preferences establish a single major piRNA 3′-end

PIWI-interacting RNAs (piRNAs) guard germline genomes against the deleterious action of mobile genetic elements. PiRNAs use extensive base-pairing to recognize their targets and variable 3′ends could change the specificity and efficacy of piRNA silencing. Here, we identify conserved rules that ensur...

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Detalles Bibliográficos
Autores principales: Stoyko, Daniel, Genzor, Pavol, Haase, Astrid D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162947/
https://www.ncbi.nlm.nih.gov/pubmed/35669519
http://dx.doi.org/10.1016/j.isci.2022.104427