αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading

Alpha(α)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if: (1) plasma αKlotho was reduced after both spaceflight aboard the ISS...

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Detalles Bibliográficos
Autores principales: Willey, Jeffrey S., Aunon-Chancellor, Serena, Miles, Lauren A., Moore, Joseph E., Mao, Xiao W., Wallace, Robert W., Foy, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163032/
https://www.ncbi.nlm.nih.gov/pubmed/35654945
http://dx.doi.org/10.1038/s41526-022-00203-w
Descripción
Sumario:Alpha(α)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if: (1) plasma αKlotho was reduced after both spaceflight aboard the ISS and hindlimb unloading (HU); and (2) deficiency could be reversed with exercise. Both spaceflight and HU lowered circulating plasma αKlotho: plasma αKlotho recovered with exercise after HU.

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