αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading

Alpha(α)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if: (1) plasma αKlotho was reduced after both spaceflight aboard the ISS...

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Autores principales: Willey, Jeffrey S., Aunon-Chancellor, Serena, Miles, Lauren A., Moore, Joseph E., Mao, Xiao W., Wallace, Robert W., Foy, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163032/
https://www.ncbi.nlm.nih.gov/pubmed/35654945
http://dx.doi.org/10.1038/s41526-022-00203-w
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author Willey, Jeffrey S.
Aunon-Chancellor, Serena
Miles, Lauren A.
Moore, Joseph E.
Mao, Xiao W.
Wallace, Robert W.
Foy, Matthew C.
author_facet Willey, Jeffrey S.
Aunon-Chancellor, Serena
Miles, Lauren A.
Moore, Joseph E.
Mao, Xiao W.
Wallace, Robert W.
Foy, Matthew C.
author_sort Willey, Jeffrey S.
collection PubMed
description Alpha(α)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if: (1) plasma αKlotho was reduced after both spaceflight aboard the ISS and hindlimb unloading (HU); and (2) deficiency could be reversed with exercise. Both spaceflight and HU lowered circulating plasma αKlotho: plasma αKlotho recovered with exercise after HU.
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spelling pubmed-91630322022-06-05 αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading Willey, Jeffrey S. Aunon-Chancellor, Serena Miles, Lauren A. Moore, Joseph E. Mao, Xiao W. Wallace, Robert W. Foy, Matthew C. NPJ Microgravity Brief Communication Alpha(α)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if: (1) plasma αKlotho was reduced after both spaceflight aboard the ISS and hindlimb unloading (HU); and (2) deficiency could be reversed with exercise. Both spaceflight and HU lowered circulating plasma αKlotho: plasma αKlotho recovered with exercise after HU. Nature Publishing Group UK 2022-06-02 /pmc/articles/PMC9163032/ /pubmed/35654945 http://dx.doi.org/10.1038/s41526-022-00203-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Willey, Jeffrey S.
Aunon-Chancellor, Serena
Miles, Lauren A.
Moore, Joseph E.
Mao, Xiao W.
Wallace, Robert W.
Foy, Matthew C.
αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading
title αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading
title_full αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading
title_fullStr αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading
title_full_unstemmed αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading
title_short αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading
title_sort αklotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163032/
https://www.ncbi.nlm.nih.gov/pubmed/35654945
http://dx.doi.org/10.1038/s41526-022-00203-w
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