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Mycobiota composition and changes across pregnancy in patients with gestational diabetes mellitus (GDM)
The gut mycobiota has never been studied either during pregnancy or in patients with gestational diabetes (GDM). This study aimed to analyze the fecal mycobiota of GDM patients during the second (T2) and third (T3) trimester of pregnancy and to compare it with the mycobiota of pregnant normoglycemic...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163055/ https://www.ncbi.nlm.nih.gov/pubmed/35654937 http://dx.doi.org/10.1038/s41598-022-13438-0 |
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author | Ferrocino, Ilario Ponzo, Valentina Pellegrini, Marianna Goitre, Ilaria Papurello, Matteo Franciosa, Irene D’Eusebio, Chiara Ghigo, Ezio Cocolin, Luca Bo, Simona |
author_facet | Ferrocino, Ilario Ponzo, Valentina Pellegrini, Marianna Goitre, Ilaria Papurello, Matteo Franciosa, Irene D’Eusebio, Chiara Ghigo, Ezio Cocolin, Luca Bo, Simona |
author_sort | Ferrocino, Ilario |
collection | PubMed |
description | The gut mycobiota has never been studied either during pregnancy or in patients with gestational diabetes (GDM). This study aimed to analyze the fecal mycobiota of GDM patients during the second (T2) and third (T3) trimester of pregnancy and to compare it with the mycobiota of pregnant normoglycemic women (controls). Forty-one GDM patients and 121 normoglycemic women were studied. GDM mycobiota was composed almost exclusively by the Ascomycota phylum; Basidiomicota accounted for 43% of the relative frequency of the controls. Kluyveromyces (p < 0.001), Metschnikowia (p < 0.001), and Pichia (p < 0.001) showed a significantly higher frequency in GDM patients, while Saccharomyces (p = 0.019), were more prevalent in controls. From T2 to T3, a reduction in fungal alpha diversity was found in GDM patients, with an increase of the relative frequency of Candida, and the reduction of some pro-inflammatory taxa. Many associations between fungi and foods and nutrients were detected. Finally, several fungi and bacteria showed competition or co-occurrence. Patients with GDM showed a predominance of fungal taxa with potential inflammatory effects when compared to normoglycemic pregnant women, with a marked shift in their mycobiota during pregnancy, and complex bacteria-fungi interactions. |
format | Online Article Text |
id | pubmed-9163055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91630552022-06-05 Mycobiota composition and changes across pregnancy in patients with gestational diabetes mellitus (GDM) Ferrocino, Ilario Ponzo, Valentina Pellegrini, Marianna Goitre, Ilaria Papurello, Matteo Franciosa, Irene D’Eusebio, Chiara Ghigo, Ezio Cocolin, Luca Bo, Simona Sci Rep Article The gut mycobiota has never been studied either during pregnancy or in patients with gestational diabetes (GDM). This study aimed to analyze the fecal mycobiota of GDM patients during the second (T2) and third (T3) trimester of pregnancy and to compare it with the mycobiota of pregnant normoglycemic women (controls). Forty-one GDM patients and 121 normoglycemic women were studied. GDM mycobiota was composed almost exclusively by the Ascomycota phylum; Basidiomicota accounted for 43% of the relative frequency of the controls. Kluyveromyces (p < 0.001), Metschnikowia (p < 0.001), and Pichia (p < 0.001) showed a significantly higher frequency in GDM patients, while Saccharomyces (p = 0.019), were more prevalent in controls. From T2 to T3, a reduction in fungal alpha diversity was found in GDM patients, with an increase of the relative frequency of Candida, and the reduction of some pro-inflammatory taxa. Many associations between fungi and foods and nutrients were detected. Finally, several fungi and bacteria showed competition or co-occurrence. Patients with GDM showed a predominance of fungal taxa with potential inflammatory effects when compared to normoglycemic pregnant women, with a marked shift in their mycobiota during pregnancy, and complex bacteria-fungi interactions. Nature Publishing Group UK 2022-06-02 /pmc/articles/PMC9163055/ /pubmed/35654937 http://dx.doi.org/10.1038/s41598-022-13438-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Ferrocino, Ilario Ponzo, Valentina Pellegrini, Marianna Goitre, Ilaria Papurello, Matteo Franciosa, Irene D’Eusebio, Chiara Ghigo, Ezio Cocolin, Luca Bo, Simona Mycobiota composition and changes across pregnancy in patients with gestational diabetes mellitus (GDM) |
title | Mycobiota composition and changes across pregnancy in patients with gestational diabetes mellitus (GDM) |
title_full | Mycobiota composition and changes across pregnancy in patients with gestational diabetes mellitus (GDM) |
title_fullStr | Mycobiota composition and changes across pregnancy in patients with gestational diabetes mellitus (GDM) |
title_full_unstemmed | Mycobiota composition and changes across pregnancy in patients with gestational diabetes mellitus (GDM) |
title_short | Mycobiota composition and changes across pregnancy in patients with gestational diabetes mellitus (GDM) |
title_sort | mycobiota composition and changes across pregnancy in patients with gestational diabetes mellitus (gdm) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163055/ https://www.ncbi.nlm.nih.gov/pubmed/35654937 http://dx.doi.org/10.1038/s41598-022-13438-0 |
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