Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1

The DNA methylation status of the X-chromosome in cancer cells is often overlooked because of computational difficulties. Most of the CpG islands on the X-chromosome are mono-allelically methylated in normal female cells and only present as a single copy in male cells. We treated two colorectal canc...

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Detalles Bibliográficos
Autores principales: Wiseman, Ashley K., Tiedemann, Rochelle L., Fan, Huihui, Shen, Hui, Madaj, Zachary, McCabe, Michael T., Pappalardi, Melissa B., Jones, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163065/
https://www.ncbi.nlm.nih.gov/pubmed/35654826
http://dx.doi.org/10.1038/s42003-022-03509-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163065/
https://www.ncbi.nlm.nih.gov/pubmed/35654826
http://dx.doi.org/10.1038/s42003-022-03509-3

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