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Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1
The DNA methylation status of the X-chromosome in cancer cells is often overlooked because of computational difficulties. Most of the CpG islands on the X-chromosome are mono-allelically methylated in normal female cells and only present as a single copy in male cells. We treated two colorectal canc...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163065/ https://www.ncbi.nlm.nih.gov/pubmed/35654826 http://dx.doi.org/10.1038/s42003-022-03509-3 |