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Time-resolved structure-function coupling in brain networks
The relationship between structural and functional connectivity in the brain is a key question in systems neuroscience. Modern accounts assume a single global structure-function relationship that persists over time. Here we study structure-function coupling from a dynamic perspective, and show that...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163085/ https://www.ncbi.nlm.nih.gov/pubmed/35654886 http://dx.doi.org/10.1038/s42003-022-03466-x |
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author | Liu, Zhen-Qi Vázquez-Rodríguez, Bertha Spreng, R. Nathan Bernhardt, Boris C. Betzel, Richard F. Misic, Bratislav |
author_facet | Liu, Zhen-Qi Vázquez-Rodríguez, Bertha Spreng, R. Nathan Bernhardt, Boris C. Betzel, Richard F. Misic, Bratislav |
author_sort | Liu, Zhen-Qi |
collection | PubMed |
description | The relationship between structural and functional connectivity in the brain is a key question in systems neuroscience. Modern accounts assume a single global structure-function relationship that persists over time. Here we study structure-function coupling from a dynamic perspective, and show that it is regionally heterogeneous. We use a temporal unwrapping procedure to identify moment-to-moment co-fluctuations in neural activity, and reconstruct time-resolved structure-function coupling patterns. We find that patterns of dynamic structure-function coupling are region-specific. We observe stable coupling in unimodal and transmodal cortex, and dynamic coupling in intermediate regions, particularly in insular cortex (salience network) and frontal eye fields (dorsal attention network). Finally, we show that the variability of a region’s structure-function coupling is related to the distribution of its connection lengths. Collectively, our findings provide a way to study structure-function relationships from a dynamic perspective. |
format | Online Article Text |
id | pubmed-9163085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91630852022-06-05 Time-resolved structure-function coupling in brain networks Liu, Zhen-Qi Vázquez-Rodríguez, Bertha Spreng, R. Nathan Bernhardt, Boris C. Betzel, Richard F. Misic, Bratislav Commun Biol Article The relationship between structural and functional connectivity in the brain is a key question in systems neuroscience. Modern accounts assume a single global structure-function relationship that persists over time. Here we study structure-function coupling from a dynamic perspective, and show that it is regionally heterogeneous. We use a temporal unwrapping procedure to identify moment-to-moment co-fluctuations in neural activity, and reconstruct time-resolved structure-function coupling patterns. We find that patterns of dynamic structure-function coupling are region-specific. We observe stable coupling in unimodal and transmodal cortex, and dynamic coupling in intermediate regions, particularly in insular cortex (salience network) and frontal eye fields (dorsal attention network). Finally, we show that the variability of a region’s structure-function coupling is related to the distribution of its connection lengths. Collectively, our findings provide a way to study structure-function relationships from a dynamic perspective. Nature Publishing Group UK 2022-06-02 /pmc/articles/PMC9163085/ /pubmed/35654886 http://dx.doi.org/10.1038/s42003-022-03466-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Liu, Zhen-Qi Vázquez-Rodríguez, Bertha Spreng, R. Nathan Bernhardt, Boris C. Betzel, Richard F. Misic, Bratislav Time-resolved structure-function coupling in brain networks |
title | Time-resolved structure-function coupling in brain networks |
title_full | Time-resolved structure-function coupling in brain networks |
title_fullStr | Time-resolved structure-function coupling in brain networks |
title_full_unstemmed | Time-resolved structure-function coupling in brain networks |
title_short | Time-resolved structure-function coupling in brain networks |
title_sort | time-resolved structure-function coupling in brain networks |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163085/ https://www.ncbi.nlm.nih.gov/pubmed/35654886 http://dx.doi.org/10.1038/s42003-022-03466-x |
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