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Early response competition over the motor cortex underlies proactive control of error correction

Response inhibition is a fundamental brain function that must be flexible enough to incorporate proactive goal-directed demands, along with reactive, automatic and well consolidated behaviors. However, whether proactive inhibitory processes can be explained by response competition, rather than by ac...

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Autores principales: Rodríguez-Herreros, Borja, Amengual, Julià L., Vázquez-Anguiano, Jimena Lucrecia, Ionta, Silvio, Miniussi, Carlo, Cunillera, Toni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163130/
https://www.ncbi.nlm.nih.gov/pubmed/35654955
http://dx.doi.org/10.1038/s41598-022-12928-5
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author Rodríguez-Herreros, Borja
Amengual, Julià L.
Vázquez-Anguiano, Jimena Lucrecia
Ionta, Silvio
Miniussi, Carlo
Cunillera, Toni
author_facet Rodríguez-Herreros, Borja
Amengual, Julià L.
Vázquez-Anguiano, Jimena Lucrecia
Ionta, Silvio
Miniussi, Carlo
Cunillera, Toni
author_sort Rodríguez-Herreros, Borja
collection PubMed
description Response inhibition is a fundamental brain function that must be flexible enough to incorporate proactive goal-directed demands, along with reactive, automatic and well consolidated behaviors. However, whether proactive inhibitory processes can be explained by response competition, rather than by active top-down inhibitory control, remains still unclear. Using a modified version of the Eriksen flanker task, we examined the behavioral and electrophysiological correlates elicited by manipulating the degree of inhibitory control in a task that involved the fast amendment of errors. We observed that restraining or encouraging the correction of errors did not affect the behavioral and neural correlates associated to reactive inhibition. We rather found that an early, sustained and bilateral activation, of both the correct and the incorrect response, was required for an effective proactive inhibitory control. Selective unilateral patterns of response preparation were instead associated with defective response suppression. Our results provide behavioral and electrophysiological evidence of a simultaneous dual pre-activation of two motor commands, likely underlying a global operating mechanism suggesting competition or lateral inhibition to govern the amendment of errors. These findings are consistent with the response inhibitory processes already observed in speed-accuracy tradeoff studies, and hint at a decisive role of early response competition to determine the success of multiple-choice action selection.
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spelling pubmed-91631302022-06-05 Early response competition over the motor cortex underlies proactive control of error correction Rodríguez-Herreros, Borja Amengual, Julià L. Vázquez-Anguiano, Jimena Lucrecia Ionta, Silvio Miniussi, Carlo Cunillera, Toni Sci Rep Article Response inhibition is a fundamental brain function that must be flexible enough to incorporate proactive goal-directed demands, along with reactive, automatic and well consolidated behaviors. However, whether proactive inhibitory processes can be explained by response competition, rather than by active top-down inhibitory control, remains still unclear. Using a modified version of the Eriksen flanker task, we examined the behavioral and electrophysiological correlates elicited by manipulating the degree of inhibitory control in a task that involved the fast amendment of errors. We observed that restraining or encouraging the correction of errors did not affect the behavioral and neural correlates associated to reactive inhibition. We rather found that an early, sustained and bilateral activation, of both the correct and the incorrect response, was required for an effective proactive inhibitory control. Selective unilateral patterns of response preparation were instead associated with defective response suppression. Our results provide behavioral and electrophysiological evidence of a simultaneous dual pre-activation of two motor commands, likely underlying a global operating mechanism suggesting competition or lateral inhibition to govern the amendment of errors. These findings are consistent with the response inhibitory processes already observed in speed-accuracy tradeoff studies, and hint at a decisive role of early response competition to determine the success of multiple-choice action selection. Nature Publishing Group UK 2022-06-02 /pmc/articles/PMC9163130/ /pubmed/35654955 http://dx.doi.org/10.1038/s41598-022-12928-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Rodríguez-Herreros, Borja
Amengual, Julià L.
Vázquez-Anguiano, Jimena Lucrecia
Ionta, Silvio
Miniussi, Carlo
Cunillera, Toni
Early response competition over the motor cortex underlies proactive control of error correction
title Early response competition over the motor cortex underlies proactive control of error correction
title_full Early response competition over the motor cortex underlies proactive control of error correction
title_fullStr Early response competition over the motor cortex underlies proactive control of error correction
title_full_unstemmed Early response competition over the motor cortex underlies proactive control of error correction
title_short Early response competition over the motor cortex underlies proactive control of error correction
title_sort early response competition over the motor cortex underlies proactive control of error correction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163130/
https://www.ncbi.nlm.nih.gov/pubmed/35654955
http://dx.doi.org/10.1038/s41598-022-12928-5
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