Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity

The determinants of severe COVID-19 in healthy adults are poorly understood, which limits the opportunity for early intervention. We present a multiomic analysis using machine learning to characterize the genomic basis of COVID-19 severity. We use single-cell multiome profiling of human lungs to lin...

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Detalles Bibliográficos
Autores principales: Zhang, Sai, Cooper-Knock, Johnathan, Weimer, Annika K., Shi, Minyi, Kozhaya, Lina, Unutmaz, Derya, Harvey, Calum, Julian, Thomas H., Furini, Simone, Frullanti, Elisa, Fava, Francesca, Renieri, Alessandra, Gao, Peng, Shen, Xiaotao, Timpanaro, Ilia Sarah, Kenna, Kevin P., Baillie, J. Kenneth, Davis, Mark M., Tsao, Philip S., Snyder, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163145/
https://www.ncbi.nlm.nih.gov/pubmed/35690068
http://dx.doi.org/10.1016/j.cels.2022.05.007

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