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Prediction of Early Mortality Among Children With Moderate or Severe Traumatic Brain Injury Based on a Nomogram Integrating Radiological and Inflammation-Based Biomarkers

Inflammation-based scores have been increasingly used for prognosis prediction in neurological diseases. This study aimed to investigate the predictive value of inflammation-based scores combined with radiological characteristics in children with moderate or severe traumatic brain injury (MS-TBI). A...

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Autores principales: Zhu, Pingyi, Hussein, Nimo Mohamed, Tang, Jing, Lin, Lulu, Wang, Yu, Li, Lan, Shu, Kun, Zou, Pinfa, Xia, Yikai, Bai, Guanghui, Yan, Zhihan, Ye, Xinjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163313/
https://www.ncbi.nlm.nih.gov/pubmed/35669876
http://dx.doi.org/10.3389/fneur.2022.865084
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author Zhu, Pingyi
Hussein, Nimo Mohamed
Tang, Jing
Lin, Lulu
Wang, Yu
Li, Lan
Shu, Kun
Zou, Pinfa
Xia, Yikai
Bai, Guanghui
Yan, Zhihan
Ye, Xinjian
author_facet Zhu, Pingyi
Hussein, Nimo Mohamed
Tang, Jing
Lin, Lulu
Wang, Yu
Li, Lan
Shu, Kun
Zou, Pinfa
Xia, Yikai
Bai, Guanghui
Yan, Zhihan
Ye, Xinjian
author_sort Zhu, Pingyi
collection PubMed
description Inflammation-based scores have been increasingly used for prognosis prediction in neurological diseases. This study aimed to investigate the predictive value of inflammation-based scores combined with radiological characteristics in children with moderate or severe traumatic brain injury (MS-TBI). A total of 104 pediatric patients with MS-TBI were retrospectively enrolled and randomly divided into training and validation cohorts at a 7:3 ratio. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of prognosis in pediatric patients with MS-TBI. A prognostic nomogram was constructed, and its predictive performance was validated in both the training and validation cohorts. Sex, admission platelet-to-lymphocyte ratio, and basal cistern status from initial CT findings were identified as independent prognostic predictors for children with MS-TBI in multivariate logistic analysis. Based on these findings, a nomogram was then developed and its concordance index values were 0.918 [95% confidence interval (CI): 0.837–0.999] in the training cohort and 0.86 (95% CI: 0.70–1.00) in the validation cohort, which significantly outperformed those of the Rotterdam, Marshall, and Helsinki CT scores. The proposed nomogram, based on routine complete blood count and initial CT scan findings, can contribute to individualized prognosis prediction and clinical decision-making in children with MS-TBI.
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spelling pubmed-91633132022-06-05 Prediction of Early Mortality Among Children With Moderate or Severe Traumatic Brain Injury Based on a Nomogram Integrating Radiological and Inflammation-Based Biomarkers Zhu, Pingyi Hussein, Nimo Mohamed Tang, Jing Lin, Lulu Wang, Yu Li, Lan Shu, Kun Zou, Pinfa Xia, Yikai Bai, Guanghui Yan, Zhihan Ye, Xinjian Front Neurol Neurology Inflammation-based scores have been increasingly used for prognosis prediction in neurological diseases. This study aimed to investigate the predictive value of inflammation-based scores combined with radiological characteristics in children with moderate or severe traumatic brain injury (MS-TBI). A total of 104 pediatric patients with MS-TBI were retrospectively enrolled and randomly divided into training and validation cohorts at a 7:3 ratio. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of prognosis in pediatric patients with MS-TBI. A prognostic nomogram was constructed, and its predictive performance was validated in both the training and validation cohorts. Sex, admission platelet-to-lymphocyte ratio, and basal cistern status from initial CT findings were identified as independent prognostic predictors for children with MS-TBI in multivariate logistic analysis. Based on these findings, a nomogram was then developed and its concordance index values were 0.918 [95% confidence interval (CI): 0.837–0.999] in the training cohort and 0.86 (95% CI: 0.70–1.00) in the validation cohort, which significantly outperformed those of the Rotterdam, Marshall, and Helsinki CT scores. The proposed nomogram, based on routine complete blood count and initial CT scan findings, can contribute to individualized prognosis prediction and clinical decision-making in children with MS-TBI. Frontiers Media S.A. 2022-05-20 /pmc/articles/PMC9163313/ /pubmed/35669876 http://dx.doi.org/10.3389/fneur.2022.865084 Text en Copyright © 2022 Zhu, Hussein, Tang, Lin, Wang, Li, Shu, Zou, Xia, Bai, Yan and Ye. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Zhu, Pingyi
Hussein, Nimo Mohamed
Tang, Jing
Lin, Lulu
Wang, Yu
Li, Lan
Shu, Kun
Zou, Pinfa
Xia, Yikai
Bai, Guanghui
Yan, Zhihan
Ye, Xinjian
Prediction of Early Mortality Among Children With Moderate or Severe Traumatic Brain Injury Based on a Nomogram Integrating Radiological and Inflammation-Based Biomarkers
title Prediction of Early Mortality Among Children With Moderate or Severe Traumatic Brain Injury Based on a Nomogram Integrating Radiological and Inflammation-Based Biomarkers
title_full Prediction of Early Mortality Among Children With Moderate or Severe Traumatic Brain Injury Based on a Nomogram Integrating Radiological and Inflammation-Based Biomarkers
title_fullStr Prediction of Early Mortality Among Children With Moderate or Severe Traumatic Brain Injury Based on a Nomogram Integrating Radiological and Inflammation-Based Biomarkers
title_full_unstemmed Prediction of Early Mortality Among Children With Moderate or Severe Traumatic Brain Injury Based on a Nomogram Integrating Radiological and Inflammation-Based Biomarkers
title_short Prediction of Early Mortality Among Children With Moderate or Severe Traumatic Brain Injury Based on a Nomogram Integrating Radiological and Inflammation-Based Biomarkers
title_sort prediction of early mortality among children with moderate or severe traumatic brain injury based on a nomogram integrating radiological and inflammation-based biomarkers
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163313/
https://www.ncbi.nlm.nih.gov/pubmed/35669876
http://dx.doi.org/10.3389/fneur.2022.865084
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