Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting

The pathological hallmark of neurodegenerative diseases is the formation of toxic oligomers by proteins such as alpha-synuclein (aSyn) or microtubule-associated protein tau (Tau). Consequently, such oligomers are promising biomarker candidates for diagnostics as well as drug development. However, me...

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Detalles Bibliográficos
Autores principales: Blömeke, Lara, Pils, Marlene, Kraemer-Schulien, Victoria, Dybala, Alexandra, Schaffrath, Anja, Kulawik, Andreas, Rehn, Fabian, Cousin, Anneliese, Nischwitz, Volker, Willbold, Johannes, Zack, Rebecca, Tropea, Thomas F., Bujnicki, Tuyen, Tamgüney, Gültekin, Weintraub, Daniel, Irwin, David, Grossman, Murray, Wolk, David A., Trojanowski, John Q., Bannach, Oliver, Chen-Plotkin, Alice, Willbold, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163356/
https://www.ncbi.nlm.nih.gov/pubmed/35655068
http://dx.doi.org/10.1038/s41531-022-00330-x

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